Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors

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72 Citations (Scopus)

Abstract

The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible strategies are to target CB1 receptors present on neurones outside the central nervous system or novel types or subtypes of neuronal cannabinoid receptor. This paper reviews evidence for the presence of CB1 receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.

Original languageEnglish
Pages (from-to)597-605
Number of pages9
JournalLife Sciences
Volume65
Publication statusPublished - 1999

Keywords

  • peripheral cannabinoid CB1 receptors
  • CB2-like receptors
  • AM630
  • guinea-pig small intestine
  • mouse vas deferens
  • palmitoylethanolamide
  • PIG SMALL-INTESTINE
  • ELECTRICALLY-EVOKED CONTRACTIONS
  • MOUSE VAS-DEFERENS
  • RAT-BRAIN
  • MYENTERIC PLEXUS
  • SELECTIVE ANTAGONIST
  • BINDING
  • ANANDAMIDE
  • AGONISTS
  • INHIBITION

Cite this

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title = "Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors",
abstract = "The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible strategies are to target CB1 receptors present on neurones outside the central nervous system or novel types or subtypes of neuronal cannabinoid receptor. This paper reviews evidence for the presence of CB1 receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.",
keywords = "peripheral cannabinoid CB1 receptors, CB2-like receptors, AM630, guinea-pig small intestine, mouse vas deferens, palmitoylethanolamide, PIG SMALL-INTESTINE, ELECTRICALLY-EVOKED CONTRACTIONS, MOUSE VAS-DEFERENS, RAT-BRAIN, MYENTERIC PLEXUS, SELECTIVE ANTAGONIST, BINDING, ANANDAMIDE, AGONISTS, INHIBITION",
author = "Pertwee, {R G}",
year = "1999",
language = "English",
volume = "65",
pages = "597--605",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors

AU - Pertwee, R G

PY - 1999

Y1 - 1999

N2 - The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible strategies are to target CB1 receptors present on neurones outside the central nervous system or novel types or subtypes of neuronal cannabinoid receptor. This paper reviews evidence for the presence of CB1 receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.

AB - The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible strategies are to target CB1 receptors present on neurones outside the central nervous system or novel types or subtypes of neuronal cannabinoid receptor. This paper reviews evidence for the presence of CB1 receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.

KW - peripheral cannabinoid CB1 receptors

KW - CB2-like receptors

KW - AM630

KW - guinea-pig small intestine

KW - mouse vas deferens

KW - palmitoylethanolamide

KW - PIG SMALL-INTESTINE

KW - ELECTRICALLY-EVOKED CONTRACTIONS

KW - MOUSE VAS-DEFERENS

KW - RAT-BRAIN

KW - MYENTERIC PLEXUS

KW - SELECTIVE ANTAGONIST

KW - BINDING

KW - ANANDAMIDE

KW - AGONISTS

KW - INHIBITION

M3 - Article

VL - 65

SP - 597

EP - 605

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

ER -