Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry

Maria Rosaria Ruggiero; Simona Baroni; Stefania Pezzana; Gianni Ferrante; Simonetta Geninatti Crich; Silvio Aime

doi:10.1002/anie.201713318

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry

Maria Rosaria Ruggiero, Simona Baroni, Stefania Pezzana, Gianni Ferrante, Simonetta Geninatti Crich^*, Silvio Aime

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

6 Downloads (Pure)

Abstract

It was established through in vivo T₁ measurements at low magnetic fields that tumour cells display proton T₁ values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T₁ parallels the aggressiveness of the investigated tumour. The T₁ lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na⁺/K⁺ ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T₁ at different magnetic field strengths ranging from 0.2 to 200 mT.

Original language	English
Pages (from-to)	7468-7472
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	25
Early online date	14 Apr 2018
DOIs	https://doi.org/10.1002/anie.201713318
Publication status	Published - 18 Jun 2018

Bibliographical note

This project has received funding from the European UnionQs Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”), and it was performed in the framework of the Consorzio CIRCMSB and
of COST Action AC15209 (EURELAX)

Keywords

intracellular water lifetime
magnetic resonance imaging
relaxometry
tumor detection

Access to Document

10.1002/anie.201713318Licence: CC BY

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Final published version, 4.82 MBLicence: CC BY

Cite this

@article{2f570a14956e4e7d8f7981b52d752120,

title = "Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry",

abstract = "It was established through in vivo T1 measurements at low magnetic fields that tumour cells display proton T1 values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200 mT.",

keywords = "intracellular water lifetime, magnetic resonance imaging, relaxometry, tumor detection",

author = "Ruggiero, {Maria Rosaria} and Simona Baroni and Stefania Pezzana and Gianni Ferrante and {Geninatti Crich}, Simonetta and Silvio Aime",

note = "This project has received funding from the European UnionQs Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”), and it was performed in the framework of the Consorzio CIRCMSB and of COST Action AC15209 (EURELAX)",

year = "2018",

month = jun,

day = "18",

doi = "10.1002/anie.201713318",

language = "English",

volume = "57",

pages = "7468--7472",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "WILEY-V C H VERLAG GMBH",

number = "25",

}

TY - JOUR

T1 - Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry

AU - Ruggiero, Maria Rosaria

AU - Baroni, Simona

AU - Pezzana, Stefania

AU - Ferrante, Gianni

AU - Geninatti Crich, Simonetta

AU - Aime, Silvio

N1 - This project has received funding from the European UnionQs Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”), and it was performed in the framework of the Consorzio CIRCMSB and of COST Action AC15209 (EURELAX)

PY - 2018/6/18

Y1 - 2018/6/18

N2 - It was established through in vivo T1 measurements at low magnetic fields that tumour cells display proton T1 values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200 mT.

AB - It was established through in vivo T1 measurements at low magnetic fields that tumour cells display proton T1 values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200 mT.

KW - intracellular water lifetime

KW - magnetic resonance imaging

KW - relaxometry

KW - tumor detection

UR - http://www.scopus.com/inward/record.url?scp=85045323846&partnerID=8YFLogxK

U2 - 10.1002/anie.201713318

DO - 10.1002/anie.201713318

M3 - Article

AN - SCOPUS:85045323846

SN - 1433-7851

VL - 57

SP - 7468

EP - 7472

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 25

ER -

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this