Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies

Alison Murray MacLeod, R J MASON, D A POWER, A J MATHER, N EDWARD, Keith Nicol Stewart, W G SHEWAN, Stanislaw Urbaniak, G R D CATTO

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have previously shown that the presence in pretransplant recipient sera of Fc receptor blocking anti-bodies detected by the EA inhibition assay is correlated with improved allograft survival. Twenty-four such sera were assessed for the presence of autoantibodies by the EA inhibition and lymphocytotoxicity assays. No autolymphocytotoxic antibodies were found, and autologous EA inhibition was noted in only one case. EAinhibiting alloantibodies did occur, and their presence was correlated with improved allograft survival. Sera from 37 dialysis patients were also studied, and neither autologous EA inhibiting nor autologous lymphocytotoxic antibodies were present. Thus Fc receptor blocking alloantibodies that were correlated with improved renal transplant survival were not autoantibodies.
Original languageEnglish
Pages (from-to)520-523
Number of pages4
JournalTransplantation
Volume39
Issue number5
Publication statusPublished - May 1985

Cite this

MacLeod, A. M., MASON, R. J., POWER, D. A., MATHER, A. J., EDWARD, N., Stewart, K. N., ... CATTO, G. R. D. (1985). Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies. Transplantation, 39(5), 520-523.

Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies. / MacLeod, Alison Murray; MASON, R J ; POWER, D A ; MATHER, A J ; EDWARD, N ; Stewart, Keith Nicol; SHEWAN, W G ; Urbaniak, Stanislaw; CATTO, G R D .

In: Transplantation, Vol. 39, No. 5, 05.1985, p. 520-523.

Research output: Contribution to journalArticle

MacLeod, AM, MASON, RJ, POWER, DA, MATHER, AJ, EDWARD, N, Stewart, KN, SHEWAN, WG, Urbaniak, S & CATTO, GRD 1985, 'Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies' Transplantation, vol. 39, no. 5, pp. 520-523.
MacLeod AM, MASON RJ, POWER DA, MATHER AJ, EDWARD N, Stewart KN et al. Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies. Transplantation. 1985 May;39(5):520-523.
MacLeod, Alison Murray ; MASON, R J ; POWER, D A ; MATHER, A J ; EDWARD, N ; Stewart, Keith Nicol ; SHEWAN, W G ; Urbaniak, Stanislaw ; CATTO, G R D . / Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies. In: Transplantation. 1985 ; Vol. 39, No. 5. pp. 520-523.
@article{b67a132bbd2e43e7be3525f5035488b3,
title = "Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies",
abstract = "We have previously shown that the presence in pretransplant recipient sera of Fc receptor blocking anti-bodies detected by the EA inhibition assay is correlated with improved allograft survival. Twenty-four such sera were assessed for the presence of autoantibodies by the EA inhibition and lymphocytotoxicity assays. No autolymphocytotoxic antibodies were found, and autologous EA inhibition was noted in only one case. EAinhibiting alloantibodies did occur, and their presence was correlated with improved allograft survival. Sera from 37 dialysis patients were also studied, and neither autologous EA inhibiting nor autologous lymphocytotoxic antibodies were present. Thus Fc receptor blocking alloantibodies that were correlated with improved renal transplant survival were not autoantibodies.",
author = "MacLeod, {Alison Murray} and MASON, {R J} and POWER, {D A} and MATHER, {A J} and N EDWARD and Stewart, {Keith Nicol} and SHEWAN, {W G} and Stanislaw Urbaniak and CATTO, {G R D}",
year = "1985",
month = "5",
language = "English",
volume = "39",
pages = "520--523",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies

AU - MacLeod, Alison Murray

AU - MASON, R J

AU - POWER, D A

AU - MATHER, A J

AU - EDWARD, N

AU - Stewart, Keith Nicol

AU - SHEWAN, W G

AU - Urbaniak, Stanislaw

AU - CATTO, G R D

PY - 1985/5

Y1 - 1985/5

N2 - We have previously shown that the presence in pretransplant recipient sera of Fc receptor blocking anti-bodies detected by the EA inhibition assay is correlated with improved allograft survival. Twenty-four such sera were assessed for the presence of autoantibodies by the EA inhibition and lymphocytotoxicity assays. No autolymphocytotoxic antibodies were found, and autologous EA inhibition was noted in only one case. EAinhibiting alloantibodies did occur, and their presence was correlated with improved allograft survival. Sera from 37 dialysis patients were also studied, and neither autologous EA inhibiting nor autologous lymphocytotoxic antibodies were present. Thus Fc receptor blocking alloantibodies that were correlated with improved renal transplant survival were not autoantibodies.

AB - We have previously shown that the presence in pretransplant recipient sera of Fc receptor blocking anti-bodies detected by the EA inhibition assay is correlated with improved allograft survival. Twenty-four such sera were assessed for the presence of autoantibodies by the EA inhibition and lymphocytotoxicity assays. No autolymphocytotoxic antibodies were found, and autologous EA inhibition was noted in only one case. EAinhibiting alloantibodies did occur, and their presence was correlated with improved allograft survival. Sera from 37 dialysis patients were also studied, and neither autologous EA inhibiting nor autologous lymphocytotoxic antibodies were present. Thus Fc receptor blocking alloantibodies that were correlated with improved renal transplant survival were not autoantibodies.

M3 - Article

VL - 39

SP - 520

EP - 523

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 5

ER -