Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies

Alison Murray MacLeod, R J MASON, D A POWER, A J MATHER, N EDWARD, Keith Nicol Stewart, W G SHEWAN, Stanislaw Urbaniak, G R D CATTO

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Abstract

We have previously shown that the presence in pretransplant recipient sera of Fc receptor blocking anti-bodies detected by the EA inhibition assay is correlated with improved allograft survival. Twenty-four such sera were assessed for the presence of autoantibodies by the EA inhibition and lymphocytotoxicity assays. No autolymphocytotoxic antibodies were found, and autologous EA inhibition was noted in only one case. EAinhibiting alloantibodies did occur, and their presence was correlated with improved allograft survival. Sera from 37 dialysis patients were also studied, and neither autologous EA inhibiting nor autologous lymphocytotoxic antibodies were present. Thus Fc receptor blocking alloantibodies that were correlated with improved renal transplant survival were not autoantibodies.
Original languageEnglish
Pages (from-to)520-523
Number of pages4
JournalTransplantation
Volume39
Issue number5
Publication statusPublished - May 1985

Cite this

MacLeod, A. M., MASON, R. J., POWER, D. A., MATHER, A. J., EDWARD, N., Stewart, K. N., SHEWAN, W. G., Urbaniak, S., & CATTO, G. R. D. (1985). Evidence that Protective FC-Receptor-Blocking Antibodies in Renal-Transplantation are Alloantibodies Not Autoantibodies. Transplantation, 39(5), 520-523.