Evolution of IFN subgroups in bony fish - 1: Group I-III IFN exist in early ray-finned fish, with group II IFN subgroups present in the Holostean spotted gar, Lepisosteus oculatus

Fuguo Liu, Niels C Bols, Phuc H Pham, Christopher J Secombes, Jun Zou

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study helps clarify when the fish type I IFN groups/subgroups evolved, by examination of the IFN genes present in the Holostean spotted gar, Lepisosteus oculatus, in relation to the IFN genes present in the Chondrostea (sturgeon). It confirms that all three IFN groups (I-III), and group II subgroups, existed prior to the appearance of teleost fish. Preliminary expression analysis in a gar cell line (GARL) suggests these IFN genes will have a role in antiviral defence in Holostean fish, in that they are induced by poly(I:C). A refined model of IFN evolution within the actinopterygian fish is proposed.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalFish & Shellfish Immunology
Volume95
Early online date15 Oct 2019
DOIs
Publication statusPublished - Dec 2019

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