TY - JOUR
T1 - Evolution of IFN subgroups in bony fish - 1
T2 - Group I-III IFN exist in early ray-finned fish, with group II IFN subgroups present in the Holostean spotted gar, Lepisosteus oculatus
AU - Liu, Fuguo
AU - Bols, Niels C
AU - Pham, Phuc H
AU - Secombes, Christopher J
AU - Zou, Jun
N1 - Fuguo Liu was supported by a Newton International Fellowship funded by the Academy of Medical Sciences, UK (AMS, NIF004\1036).
PY - 2019/12
Y1 - 2019/12
N2 - The present study helps clarify when the fish type I IFN groups/subgroups evolved, by examination of the IFN genes present in the Holostean spotted gar, Lepisosteus oculatus, in relation to the IFN genes present in the Chondrostea (sturgeon). It confirms that all three IFN groups (I-III), and group II subgroups, existed prior to the appearance of teleost fish. Preliminary expression analysis in a gar cell line (GARL) suggests these IFN genes will have a role in antiviral defence in Holostean fish, in that they are induced by poly(I:C). A refined model of IFN evolution within the actinopterygian fish is proposed.
AB - The present study helps clarify when the fish type I IFN groups/subgroups evolved, by examination of the IFN genes present in the Holostean spotted gar, Lepisosteus oculatus, in relation to the IFN genes present in the Chondrostea (sturgeon). It confirms that all three IFN groups (I-III), and group II subgroups, existed prior to the appearance of teleost fish. Preliminary expression analysis in a gar cell line (GARL) suggests these IFN genes will have a role in antiviral defence in Holostean fish, in that they are induced by poly(I:C). A refined model of IFN evolution within the actinopterygian fish is proposed.
U2 - 10.1016/j.fsi.2019.10.032
DO - 10.1016/j.fsi.2019.10.032
M3 - Article
C2 - 31626921
SN - 1050-4648
VL - 95
SP - 163
EP - 170
JO - Fish & Shellfish Immunology
JF - Fish & Shellfish Immunology
ER -