Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Geraldine Butler, Matthew D Rasmussen, Michael F Lin, Manuel A S Santos, Sharadha Sakthikumar, Carol A Munro, Esther Rheinbay, Manfred Grabherr, Anja Forche, Jennifer L Reedy, Ino Agrafioti, Martha B Arnaud, Steven Bates, Alistair J P Brown, Sascha Brunke, Maria C Costanzo, David A Fitzpatrick, Piet W J de Groot, David Harris, Lois L Hoyer & 31 others Bernhard Hube, Frans M Klis, Chinnappa Kodira, Nicola Lennard, Mary E Logue, Ronny Martin, Aaron M Neiman, Elissavet Nikolaou, Michael A Quail, Janet Quinn, Maria C Santos, Florian F Schmitzberger, Gavin Sherlock, Prachi Shah, Kevin A T Silverstein, Marek S Skrzypek, David Soll, Rodney Staggs, Ian Stansfield, Michael P H Stumpf, Peter E Sudbery, Thyagarajan Srikantha, Qiandong Zeng, Judith Berman, Matthew Berriman, Joseph Heitman, Neil A R Gow, Michael C Lorenz, Bruce W Birren, Manolis Kellis, Christina A Cuomo

Research output: Contribution to journalArticle

592 Citations (Scopus)

Abstract

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalNature
Volume459
Issue number7247
Early online date24 May 2009
DOIs
Publication statusPublished - 4 Jun 2009

Fingerprint

Candida
Reproduction
Virulence
Genome
Genes
Genetic Code
Mycoses
Opportunistic Infections
Meiosis
Diploidy
Candida albicans
Codon
Leucine
Cell Wall
Serine
Genetic Recombination

Keywords

  • Candida
  • codon
  • conserved sequence
  • diploidy
  • evolution, molecular
  • genes, fungal
  • genome, fungal
  • meiosis
  • polymorphism, genetic
  • reproduction
  • saccharomyces
  • virulence

Cite this

Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., ... Cuomo, C. A. (2009). Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature, 459(7247), 657-662. https://doi.org/10.1038/nature08064

Evolution of pathogenicity and sexual reproduction in eight Candida genomes. / Butler, Geraldine; Rasmussen, Matthew D; Lin, Michael F; Santos, Manuel A S; Sakthikumar, Sharadha; Munro, Carol A; Rheinbay, Esther; Grabherr, Manfred; Forche, Anja; Reedy, Jennifer L; Agrafioti, Ino; Arnaud, Martha B; Bates, Steven; Brown, Alistair J P; Brunke, Sascha; Costanzo, Maria C; Fitzpatrick, David A; de Groot, Piet W J; Harris, David; Hoyer, Lois L; Hube, Bernhard; Klis, Frans M; Kodira, Chinnappa; Lennard, Nicola; Logue, Mary E; Martin, Ronny; Neiman, Aaron M; Nikolaou, Elissavet; Quail, Michael A; Quinn, Janet; Santos, Maria C; Schmitzberger, Florian F; Sherlock, Gavin; Shah, Prachi; Silverstein, Kevin A T; Skrzypek, Marek S; Soll, David; Staggs, Rodney; Stansfield, Ian; Stumpf, Michael P H; Sudbery, Peter E; Srikantha, Thyagarajan; Zeng, Qiandong; Berman, Judith; Berriman, Matthew; Heitman, Joseph; Gow, Neil A R; Lorenz, Michael C; Birren, Bruce W; Kellis, Manolis; Cuomo, Christina A.

In: Nature, Vol. 459, No. 7247, 04.06.2009, p. 657-662.

Research output: Contribution to journalArticle

Butler, G, Rasmussen, MD, Lin, MF, Santos, MAS, Sakthikumar, S, Munro, CA, Rheinbay, E, Grabherr, M, Forche, A, Reedy, JL, Agrafioti, I, Arnaud, MB, Bates, S, Brown, AJP, Brunke, S, Costanzo, MC, Fitzpatrick, DA, de Groot, PWJ, Harris, D, Hoyer, LL, Hube, B, Klis, FM, Kodira, C, Lennard, N, Logue, ME, Martin, R, Neiman, AM, Nikolaou, E, Quail, MA, Quinn, J, Santos, MC, Schmitzberger, FF, Sherlock, G, Shah, P, Silverstein, KAT, Skrzypek, MS, Soll, D, Staggs, R, Stansfield, I, Stumpf, MPH, Sudbery, PE, Srikantha, T, Zeng, Q, Berman, J, Berriman, M, Heitman, J, Gow, NAR, Lorenz, MC, Birren, BW, Kellis, M & Cuomo, CA 2009, 'Evolution of pathogenicity and sexual reproduction in eight Candida genomes', Nature, vol. 459, no. 7247, pp. 657-662. https://doi.org/10.1038/nature08064
Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA et al. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature. 2009 Jun 4;459(7247):657-662. https://doi.org/10.1038/nature08064
Butler, Geraldine ; Rasmussen, Matthew D ; Lin, Michael F ; Santos, Manuel A S ; Sakthikumar, Sharadha ; Munro, Carol A ; Rheinbay, Esther ; Grabherr, Manfred ; Forche, Anja ; Reedy, Jennifer L ; Agrafioti, Ino ; Arnaud, Martha B ; Bates, Steven ; Brown, Alistair J P ; Brunke, Sascha ; Costanzo, Maria C ; Fitzpatrick, David A ; de Groot, Piet W J ; Harris, David ; Hoyer, Lois L ; Hube, Bernhard ; Klis, Frans M ; Kodira, Chinnappa ; Lennard, Nicola ; Logue, Mary E ; Martin, Ronny ; Neiman, Aaron M ; Nikolaou, Elissavet ; Quail, Michael A ; Quinn, Janet ; Santos, Maria C ; Schmitzberger, Florian F ; Sherlock, Gavin ; Shah, Prachi ; Silverstein, Kevin A T ; Skrzypek, Marek S ; Soll, David ; Staggs, Rodney ; Stansfield, Ian ; Stumpf, Michael P H ; Sudbery, Peter E ; Srikantha, Thyagarajan ; Zeng, Qiandong ; Berman, Judith ; Berriman, Matthew ; Heitman, Joseph ; Gow, Neil A R ; Lorenz, Michael C ; Birren, Bruce W ; Kellis, Manolis ; Cuomo, Christina A. / Evolution of pathogenicity and sexual reproduction in eight Candida genomes. In: Nature. 2009 ; Vol. 459, No. 7247. pp. 657-662.
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