Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities

Lobke Maria Vaanholt, Serge Daan, Theodore Garland, G Henk Visser

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Studies that have found a positive influence of moderate, nonexhaustive exercise on life expectancy contradict the rate-of-living theory, which predicts that high energy expenditure in exercising animals should shorten life. We investigated effects of exercise on energy metabolism and life span in male mice from lines that had been selectively bred for high voluntary wheel-running activity and from the nonselected control lines. Mice were divided into the following three groups (n = 100 per group): active high-runner mice (housed with wheels; HR+), sedentary high-runner mice (no wheels provided; HR-), and active control mice (C+). Sixty animals from each group were left undisturbed throughout their lives to create survival curves. In the remaining 40 animals in each group, energy metabolism and body composition was measured at 2, 10, 18, or 26 mo of age. Wheel-running activity was increased by approximately 50% throughout life in HR+ mice compared with C+ mice, and mass-specific daily energy expenditure was increased by approximately 30% in HR+ mice compared with both C+ mice and HR- mice. Median life span was similar in HR+ mice and HR- mice (740 and 733 d, respectively), and it was significantly shorter in these mice than it was in C+ mice (828 d). Thus, increasing the amount of voluntary aerobic exercise (as a result of selective breeding or housing with wheels) did not result in extended life span in mice, and we found no evidence for a direct link between energy expenditure and life span.
Original languageEnglish
Pages (from-to)239-51
Number of pages13
JournalPhysiological and Biochemical Zoology
Volume83
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

Body Composition
energy metabolism
Energy Metabolism
body composition
Wheels
mice
Chemical analysis
Animals
wheels
energy expenditure
exercise
Running
animals
selection methods
Life Expectancy

Cite this

Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities. / Vaanholt, Lobke Maria; Daan, Serge; Garland, Theodore; Visser, G Henk.

In: Physiological and Biochemical Zoology, Vol. 83, No. 2, 2010, p. 239-51.

Research output: Contribution to journalArticle

Vaanholt, Lobke Maria ; Daan, Serge ; Garland, Theodore ; Visser, G Henk. / Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities. In: Physiological and Biochemical Zoology. 2010 ; Vol. 83, No. 2. pp. 239-51.
@article{96eb123af7a64227a7643454ab530082,
title = "Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities",
abstract = "Studies that have found a positive influence of moderate, nonexhaustive exercise on life expectancy contradict the rate-of-living theory, which predicts that high energy expenditure in exercising animals should shorten life. We investigated effects of exercise on energy metabolism and life span in male mice from lines that had been selectively bred for high voluntary wheel-running activity and from the nonselected control lines. Mice were divided into the following three groups (n = 100 per group): active high-runner mice (housed with wheels; HR+), sedentary high-runner mice (no wheels provided; HR-), and active control mice (C+). Sixty animals from each group were left undisturbed throughout their lives to create survival curves. In the remaining 40 animals in each group, energy metabolism and body composition was measured at 2, 10, 18, or 26 mo of age. Wheel-running activity was increased by approximately 50{\%} throughout life in HR+ mice compared with C+ mice, and mass-specific daily energy expenditure was increased by approximately 30{\%} in HR+ mice compared with both C+ mice and HR- mice. Median life span was similar in HR+ mice and HR- mice (740 and 733 d, respectively), and it was significantly shorter in these mice than it was in C+ mice (828 d). Thus, increasing the amount of voluntary aerobic exercise (as a result of selective breeding or housing with wheels) did not result in extended life span in mice, and we found no evidence for a direct link between energy expenditure and life span.",
author = "Vaanholt, {Lobke Maria} and Serge Daan and Theodore Garland and Visser, {G Henk}",
year = "2010",
doi = "10.1086/648434",
language = "English",
volume = "83",
pages = "239--51",
journal = "Physiological and Biochemical Zoology",
issn = "1522-2152",
publisher = "UNIV CHICAGO PRESS",
number = "2",

}

TY - JOUR

T1 - Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities

AU - Vaanholt, Lobke Maria

AU - Daan, Serge

AU - Garland, Theodore

AU - Visser, G Henk

PY - 2010

Y1 - 2010

N2 - Studies that have found a positive influence of moderate, nonexhaustive exercise on life expectancy contradict the rate-of-living theory, which predicts that high energy expenditure in exercising animals should shorten life. We investigated effects of exercise on energy metabolism and life span in male mice from lines that had been selectively bred for high voluntary wheel-running activity and from the nonselected control lines. Mice were divided into the following three groups (n = 100 per group): active high-runner mice (housed with wheels; HR+), sedentary high-runner mice (no wheels provided; HR-), and active control mice (C+). Sixty animals from each group were left undisturbed throughout their lives to create survival curves. In the remaining 40 animals in each group, energy metabolism and body composition was measured at 2, 10, 18, or 26 mo of age. Wheel-running activity was increased by approximately 50% throughout life in HR+ mice compared with C+ mice, and mass-specific daily energy expenditure was increased by approximately 30% in HR+ mice compared with both C+ mice and HR- mice. Median life span was similar in HR+ mice and HR- mice (740 and 733 d, respectively), and it was significantly shorter in these mice than it was in C+ mice (828 d). Thus, increasing the amount of voluntary aerobic exercise (as a result of selective breeding or housing with wheels) did not result in extended life span in mice, and we found no evidence for a direct link between energy expenditure and life span.

AB - Studies that have found a positive influence of moderate, nonexhaustive exercise on life expectancy contradict the rate-of-living theory, which predicts that high energy expenditure in exercising animals should shorten life. We investigated effects of exercise on energy metabolism and life span in male mice from lines that had been selectively bred for high voluntary wheel-running activity and from the nonselected control lines. Mice were divided into the following three groups (n = 100 per group): active high-runner mice (housed with wheels; HR+), sedentary high-runner mice (no wheels provided; HR-), and active control mice (C+). Sixty animals from each group were left undisturbed throughout their lives to create survival curves. In the remaining 40 animals in each group, energy metabolism and body composition was measured at 2, 10, 18, or 26 mo of age. Wheel-running activity was increased by approximately 50% throughout life in HR+ mice compared with C+ mice, and mass-specific daily energy expenditure was increased by approximately 30% in HR+ mice compared with both C+ mice and HR- mice. Median life span was similar in HR+ mice and HR- mice (740 and 733 d, respectively), and it was significantly shorter in these mice than it was in C+ mice (828 d). Thus, increasing the amount of voluntary aerobic exercise (as a result of selective breeding or housing with wheels) did not result in extended life span in mice, and we found no evidence for a direct link between energy expenditure and life span.

U2 - 10.1086/648434

DO - 10.1086/648434

M3 - Article

C2 - 20105070

VL - 83

SP - 239

EP - 251

JO - Physiological and Biochemical Zoology

JF - Physiological and Biochemical Zoology

SN - 1522-2152

IS - 2

ER -