Expansion of signal transduction networks

B. Binder, Oliver Ebenhoeh, K. Hashimoto, R. Heinrich

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Signal transduction networks of different cell types show a largevariety in their structural design. In this paper, basic structural properties of signal transduction networks are investigated. Forthis, such networks with the recently developed method of networkexpansion are analysed. This method allows for a structural analysisof networks by calculating signal expansion profiles when providedwith certain compounds, for example growth factors, inactive kinasesand so on (seed compounds), to initiate such an expansion. The presented results may put forth valuable hints on the evolution of signalling networks.
Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalIEE Proceedings. Systems Biology
Volume153
Issue number5
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Algorithms
  • Animals
  • Cell Physiology
  • Computer Simulation
  • Humans
  • Kinetics
  • Models, Biological
  • Proteome
  • Signal Transduction

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