Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease

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Abstract

This review highlights advantages and disadvantages of experimental procedures (chemical, cellular, physiological, histochemical and epidemiological) that have been used to identify Alzheimer- and dementia-related targets for exogenous toxins, and discusses how neuronal function can be assessed experimentally, based on the evidence obtained for the neurotoxin aluminium.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalJournal of Alzheimer's Disease
Volume10
Issue number2-3
Publication statusPublished - 1 Nov 2006

Keywords

  • Aging
  • Aluminum
  • Alzheimer Disease
  • Animals
  • Calcium
  • Cell Death
  • Cognition Disorders
  • Environmental Exposure
  • Hippocampus
  • Homeostasis
  • Humans
  • Immunohistochemistry
  • Signal Transduction
  • Water
  • Toxins
  • Behaviour
  • Imaging
  • Electrophysiology
  • Calcium-channel currents
  • Spatial working-memory
  • Long-term potentiation
  • In-vivo
  • Rats
  • Exposure
  • Toxicity
  • Therapy
  • Vitro

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