Abstract
This review highlights advantages and disadvantages of experimental procedures (chemical, cellular, physiological, histochemical and epidemiological) that have been used to identify Alzheimer- and dementia-related targets for exogenous toxins, and discusses how neuronal function can be assessed experimentally, based on the evidence obtained for the neurotoxin aluminium.
| Original language | English |
|---|---|
| Pages (from-to) | 203-213 |
| Number of pages | 11 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 10 |
| Issue number | 2-3 |
| Publication status | Published - 1 Nov 2006 |
Keywords
- Aging
- Aluminum
- Alzheimer Disease
- Animals
- Calcium
- Cell Death
- Cognition Disorders
- Environmental Exposure
- Hippocampus
- Homeostasis
- Humans
- Immunohistochemistry
- Signal Transduction
- Water
- Toxins
- Behaviour
- Imaging
- Electrophysiology
- Calcium-channel currents
- Spatial working-memory
- Long-term potentiation
- In-vivo
- Rats
- Exposure
- Toxicity
- Therapy
- Vitro