Experiments on ion channels at high pressure

Alistar Gordon MacDonald

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    Abstract

    Ion channels are distinctive membrane proteins which provide a gated pathway for diffusing ions. High pressure (< 100 MPa) affects the kinetics of gating but not the conductance of the channel. Dynamic structural studies of channels at high pressure are, thus far, conspicuously absent but functional properties are studied at the single channel level with the patch clamp technique. (C) 2002 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)387-389
    Number of pages2
    JournalBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
    Volume1595
    Issue number1-2
    DOIs
    Publication statusPublished - 2002

    Keywords

    • gating
    • channel conductance
    • inactivation
    • porin
    • patch clamp
    • HYDROSTATIC-PRESSURE
    • SODIUM-CHANNELS
    • MOLECULAR-BASIS
    • MEMBRANES
    • CURRENTS
    • VOLTAGE
    • CELLS

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