Experiments on ion channels at high pressure

Alistar Gordon MacDonald

doi:10.1016/S0167-4838(01)00359-4

Experiments on ion channels at high pressure

Alistar Gordon MacDonald

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Ion channels are distinctive membrane proteins which provide a gated pathway for diffusing ions. High pressure (< 100 MPa) affects the kinetics of gating but not the conductance of the channel. Dynamic structural studies of channels at high pressure are, thus far, conspicuously absent but functional properties are studied at the single channel level with the patch clamp technique. (C) 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	387-389
Number of pages	2
Journal	Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
Volume	1595
Issue number	1-2
DOIs	https://doi.org/10.1016/S0167-4838(01)00359-4
Publication status	Published - 2002

Keywords

gating
channel conductance
inactivation
porin
patch clamp
HYDROSTATIC-PRESSURE
SODIUM-CHANNELS
MOLECULAR-BASIS
MEMBRANES
CURRENTS
VOLTAGE
CELLS

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10.1016/S0167-4838(01)00359-4

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title = "Experiments on ion channels at high pressure",

abstract = "Ion channels are distinctive membrane proteins which provide a gated pathway for diffusing ions. High pressure (< 100 MPa) affects the kinetics of gating but not the conductance of the channel. Dynamic structural studies of channels at high pressure are, thus far, conspicuously absent but functional properties are studied at the single channel level with the patch clamp technique. (C) 2002 Elsevier Science B.V. All rights reserved.",

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T1 - Experiments on ion channels at high pressure

AU - MacDonald, Alistar Gordon

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AB - Ion channels are distinctive membrane proteins which provide a gated pathway for diffusing ions. High pressure (< 100 MPa) affects the kinetics of gating but not the conductance of the channel. Dynamic structural studies of channels at high pressure are, thus far, conspicuously absent but functional properties are studied at the single channel level with the patch clamp technique. (C) 2002 Elsevier Science B.V. All rights reserved.

KW - gating

KW - channel conductance

KW - inactivation

KW - porin

KW - patch clamp

KW - HYDROSTATIC-PRESSURE

KW - SODIUM-CHANNELS

KW - MOLECULAR-BASIS

KW - MEMBRANES

KW - CURRENTS

KW - VOLTAGE

KW - CELLS

U2 - 10.1016/S0167-4838(01)00359-4

DO - 10.1016/S0167-4838(01)00359-4

M3 - Article

SN - 0167-4838

VL - 1595

SP - 387

EP - 389

JO - Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

JF - Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

IS - 1-2

ER -

Experiments on ion channels at high pressure

Abstract

Keywords

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