Exploiting the retinal vascular geometry in identifying the progression to diabetic retinopathy using penalized logistic regression and random forests

Georgios Leontidis*, Bashir Al-Diri, Andrew Hunter

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Many studies have been conducted, investigating the effects that diabetes has to the retinal vasculature. Identifying and quantifying the retinal vascular changes remains a very challenging task, due to the heterogeneity of the retina. Monitoring the progression requires follow-up studies of progressed patients, since human retina naturally adapts to many different stimuli, making it hard to associate any changes with a disease. In this novel study, data from twenty five diabetic patients, who progressed to diabetic retinopathy, were used. The progression was evaluated using multiple geometric features, like vessels widths and angles, tortuosity, central retinal artery and vein equivalent, fractal dimension, lacunarity, in addition to the corresponding descriptive statistics of them. A statistical mixed model design was used to evaluate the significance of the changes between two periods: 3 years before the onset of diabetic retinopathy and the first year of diabetic retinopathy.Moreover, the discriminative power of these featureswas evaluated using a random forests classifier and also a penalized logistic regression. The area under the ROC curve after running a ten-fold cross validation was 0.7925 and 0.785 respectively.

Original languageEnglish
Title of host publicationEmerging Trends and Advanced Technologies for Computational Intelligence
Subtitle of host publicationExtended and Selected Results from the Science and Information Conference 2015
EditorsLiming Chen, Supriya Kapoor, Rahul Bhatia
Place of PublicationCham
PublisherSpringer
Pages381-400
Number of pages20
ISBN (Electronic)9783319333533
ISBN (Print)9783319333519
DOIs
Publication statusPublished - 2016

Publication series

NameStudies in Computational Intelligence
PublisherSpringer
Volume647
ISSN (Print)1860-949X
ISSN (Electronic)1860-9503

Keywords

  • Diabetes
  • Diabetic retinopathy
  • Logistic regression
  • Mixed model
  • Random forests

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