Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

O. Gervais, A. Barria, A. Papadopoulou, R. L. Gratacap, B. Hillestad, A. E. Tinch, S. A. M. Martin, Diego Robledo, R. D. Houston

Research output: Contribution to journalArticlepeer-review

Abstract

Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.
Original languageEnglish
Article number345
Number of pages14
JournalBMC Genomics
Volume22
Issue number1
Early online date13 May 2021
DOIs
Publication statusPublished - 2021

Keywords

  • Disease resistance
  • RNA-Seq
  • Fish
  • Acquaculture
  • Salmo salar
  • TRIM25
  • GWAS
  • Heritability

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