Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

O. Gervais; A. Barria; A. Papadopoulou; R. L. Gratacap; B. Hillestad; A. E. Tinch; S. A. M. Martin; Diego Robledo; R. D. Houston

doi:10.1186/s12864-021-07671-6

Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

O. Gervais, A. Barria, A. Papadopoulou, R. L. Gratacap, B. Hillestad, A. E. Tinch, S. A. M. Martin, Diego Robledo, R. D. Houston

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Abstract

Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.

Original language	English
Article number	345
Number of pages	14
Journal	BMC Genomics
Volume	22
Issue number	1
Early online date	13 May 2021
DOIs	https://doi.org/10.1186/s12864-021-07671-6
Publication status	Published - 2021

Bibliographical note

Funding
The authors gratefully acknowledge funding from BBSRC (BB/R008612/1, BB/R008973/1), in addition to BBSRC Institute Strategic Programme Grants to the Roslin Institute (BB/P013759/1 and BB/P013740/1).

Keywords

Disease resistance
RNA-Seq
Fish
Acquaculture
Salmo salar
TRIM25
GWAS
Heritability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing",

abstract = "Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.",

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note = "Funding The authors gratefully acknowledge funding from BBSRC (BB/R008612/1, BB/R008973/1), in addition to BBSRC Institute Strategic Programme Grants to the Roslin Institute (BB/P013759/1 and BB/P013740/1).",

year = "2021",

doi = "10.1186/s12864-021-07671-6",

language = "English",

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AU - Gervais, O.

AU - Barria, A.

AU - Papadopoulou, A.

AU - Gratacap, R. L.

AU - Hillestad, B.

AU - Tinch, A. E.

AU - Martin, S. A. M.

AU - Robledo, Diego

AU - Houston, R. D.

N1 - Funding The authors gratefully acknowledge funding from BBSRC (BB/R008612/1, BB/R008973/1), in addition to BBSRC Institute Strategic Programme Grants to the Roslin Institute (BB/P013759/1 and BB/P013740/1).

PY - 2021

Y1 - 2021

N2 - Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.

AB - Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.

KW - Disease resistance

KW - RNA-Seq

KW - Fish

KW - Acquaculture

KW - Salmo salar

KW - TRIM25

KW - GWAS

KW - Heritability

U2 - 10.1186/s12864-021-07671-6

DO - 10.1186/s12864-021-07671-6

M3 - Article

SN - 1471-2164

VL - 22

JO - BMC Genomics

JF - BMC Genomics

IS - 1

M1 - 345

ER -

Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

Abstract

Bibliographical note

Keywords

UN SDGs

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