Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

O. Gervais; A. Barria; A. Papadopoulou; R. L. Gratacap; B. Hillestad; A. E. Tinch; S. A. M. Martin; Diego Robledo; R. D. Houston

doi:10.1186/s12864-021-07671-6

Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

O. Gervais, A. Barria, A. Papadopoulou, R. L. Gratacap, B. Hillestad, A. E. Tinch, S. A. M. Martin, Diego Robledo, R. D. Houston

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.

Original language	English
Article number	345
Number of pages	14
Journal	BMC Genomics
Volume	22
Issue number	1
Early online date	13 May 2021
DOIs	https://doi.org/10.1186/s12864-021-07671-6
Publication status	Published - 2021

Keywords

Disease resistance
RNA-Seq
Fish
Acquaculture
Salmo salar
TRIM25
GWAS
Heritability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12864-021-07671-6Licence: CC BY

Gervais_etal_BMCG_Exploring_Genetic_Resistance_VoR
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver
Final published version, 1.45 MBLicence: CC BY

Cite this

@article{09c2e34ed95842dc88951dc27b0d300a,

title = "Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing",

abstract = "Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.",

keywords = "Disease resistance, RNA-Seq, Fish, Acquaculture, Salmo salar, TRIM25, GWAS, Heritability",

author = "O. Gervais and A. Barria and A. Papadopoulou and Gratacap, {R. L.} and B. Hillestad and Tinch, {A. E.} and Martin, {S. A. M.} and Diego Robledo and Houston, {R. D.}",

note = "Funding The authors gratefully acknowledge funding from BBSRC (BB/R008612/1, BB/R008973/1), in addition to BBSRC Institute Strategic Programme Grants to the Roslin Institute (BB/P013759/1 and BB/P013740/1).",

year = "2021",

doi = "10.1186/s12864-021-07671-6",

language = "English",

volume = "22",

journal = "BMC Genomics",

issn = "1471-2164",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

AU - Gervais, O.

AU - Barria, A.

AU - Papadopoulou, A.

AU - Gratacap, R. L.

AU - Hillestad, B.

AU - Tinch, A. E.

AU - Martin, S. A. M.

AU - Robledo, Diego

AU - Houston, R. D.

N1 - Funding The authors gratefully acknowledge funding from BBSRC (BB/R008612/1, BB/R008973/1), in addition to BBSRC Institute Strategic Programme Grants to the Roslin Institute (BB/P013759/1 and BB/P013740/1).

PY - 2021

Y1 - 2021

N2 - Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.

AB - Infectious Salmonid Anaemia Virus (ISAV) causes a notifiable disease that poses a large threat for Atlantic salmon (Salmo salar) aquaculture worldwide. There is no fully effective treatment or vaccine, and therefore selective breeding to increase resistance to ISAV is a promising avenue for disease prevention. Genomic selection and potentially genome editing can be applied to enhance host resistance, and these approaches benefit from improved knowledge of the genetic and functional basis of the target trait. The aim of this study was to characterise the genetic architecture of resistance to ISAV in a commercial Atlantic salmon population and study its underlying functional genomic basis using RNA Sequencing.

KW - Disease resistance

KW - RNA-Seq

KW - Fish

KW - Acquaculture

KW - Salmo salar

KW - TRIM25

KW - GWAS

KW - Heritability

U2 - 10.1186/s12864-021-07671-6

DO - 10.1186/s12864-021-07671-6

M3 - Article

VL - 22

JO - BMC Genomics

JF - BMC Genomics

SN - 1471-2164

IS - 1

M1 - 345

ER -

Exploring genetic resistance to infectious salmon anaemia virus in Atlantic salmon by genome-wide association and RNA sequencing

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this