Expression of Drug Transporters in Cervicovaginal Cell Lines and Modulatory Effect of Candidate Anti-retroviral Microbicides

Kieron A Smith, Indrani Mukhopadhya, Susan Berry, Georgina L Hold, Karolin Hijazi

Research output: Contribution to journalArticle

Abstract

Drug transporters expressed in the cervicovaginal (CV) epithelium are likely to influence delivery of antiretroviral (ARV)-vaginal microbicides to subepithelial target cells for HIV-1. This study aims to characterise drug transporters in CV cell lines and investigate the impact of dapivirine (DPV) and darunavir (DRV) on gene expression for development of in vitro assays for testing transport of candidate ARV-microbicides across the CV epithelium.
Original languageEnglish
Article numberP31.02
Pages (from-to)A201
JournalAIDS Research and Human Retroviruses
Volume30
Issue numberSuppl 1
DOIs
Publication statusPublished - Oct 2014

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Anti-Infective Agents
Epithelium
Cell Line
Pharmaceutical Preparations
HIV-1
Gene Expression
Darunavir
TMC120-R147681
In Vitro Techniques

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Expression of Drug Transporters in Cervicovaginal Cell Lines and Modulatory Effect of Candidate Anti-retroviral Microbicides. / Smith, Kieron A; Mukhopadhya, Indrani; Berry, Susan; Hold, Georgina L; Hijazi, Karolin.

In: AIDS Research and Human Retroviruses, Vol. 30 , No. Suppl 1, P31.02, 10.2014, p. A201.

Research output: Contribution to journalArticle

Smith, Kieron A ; Mukhopadhya, Indrani ; Berry, Susan ; Hold, Georgina L ; Hijazi, Karolin. / Expression of Drug Transporters in Cervicovaginal Cell Lines and Modulatory Effect of Candidate Anti-retroviral Microbicides. In: AIDS Research and Human Retroviruses. 2014 ; Vol. 30 , No. Suppl 1. pp. A201.
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