Abstract
Drug transporters expressed in the cervicovaginal (CV) epithelium are likely to influence delivery of antiretroviral (ARV)-vaginal microbicides to subepithelial target cells for HIV-1. This study aims to characterise drug transporters in CV cell lines and investigate the impact of dapivirine (DPV) and darunavir (DRV) on gene expression for development of in vitro assays for testing transport of candidate ARV-microbicides across the CV epithelium.
Original language | English |
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Article number | P31.02 |
Pages (from-to) | A201 |
Journal | AIDS Research and Human Retroviruses |
Volume | 30 |
Issue number | Suppl 1 |
DOIs | |
Publication status | Published - Oct 2014 |