Expression of growth factor receptors is not a prognostic indicator in young patients with colorectal cancer

N. Langlois, L. G. Walker, I. Smith, L. Skinner, O. Eremin, S. D. Heys*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Growth factor receptor expression has been shown to be of prognostic significance in certain cancers, but its relevance in young patients with colorectal cancer is unknown. The aim of this study, therefore, is to determine the prognostic relevance of growth factor receptor expression [c-erbB-2, epidermal growth factor receptor (EGFR) and transforming growth factor β receptor (TGEβR)] in such patients. Ninety-two patients were evaluated. They were staged using the Jass staging system and the presence of metastases. The expression of EGFR and TGFβR and the protein production of c-erbB-2 were detected using standard immunohistochemical techniques. The expression of EGFR and TGFβR and the presence of the c-erbB-2 protein product were not identified as independent prognostic factors for survival. Furthermore, their expression did not correlate with established prognostic indicators such as Jass staging, the presence of extramural vascular invasion and the degree of tumour differentiation.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalJournal of the Royal College of Surgeons of Edinburgh
Volume42
Issue number2
Publication statusPublished - 1 Apr 1997

Keywords

  • Colorectal cancer
  • Growth factors
  • Young patients

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