Expression patterns of Slit and Robo family members during vertebrate limb development

Neil Vargesson, V. Luria, I. Messina, Lynda Erskine, E. Laufer

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We report the cloning and expression during limb development of the chicken Slit1, Slit2, and Slit3 ligands, and Robo1 and Robo2 receptor genes. We also compare the expression patterns of Robo1 and Robo2 in developing chick and mouse hindlimbs. These genes are expressed in regions of muscle development, chrondrogenesis, and axon guidance. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)175-180
Number of pages5
JournalMechanisms of Development
Volume106
Issue number1-2
Early online date1 Aug 2001
DOIs
Publication statusPublished - Aug 2001

Keywords

  • roundabout
  • Robo1
  • Robo2
  • Rig1
  • Slit1
  • Slit2
  • Slit3
  • chick
  • mouse
  • limb development
  • muscle
  • innervation
  • axon guidance
  • chrondrogenesis
  • gene expression
  • apical ectodermal ridge
  • mesenchyme
  • AXON GUIDANCE
  • MIDLINE REPELLENT
  • ROUNDABOUT
  • CNS
  • MORPHOGENESIS
  • RECEPTORS
  • PROTEINS
  • EMBRYOS
  • MUSCLE

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