A 71-year-old woman presented with dysphagia 2 years after undergoing radical chemoradiotherapy for squamous cell carcinoma of the cervical esophagus. Endoscopy revealed a benign esophageal stricture 20 cm from the incisors, with a 1-cm villiform mass below the stricture (A). The esophageal mass increased in size over the next 4 years, completely obstructing the lumen (B) and extending over a length of 12 cm as shown by contrast swallow (C). Examination of multiple sets of biopsy specimens failed to show any evidence of atypia, high-grade dysplasia, or invasive malignancy, but histologic analysis did show multiple polypoid fragments of squamous esophageal mucosa with the appearance of squamous cell papillomatosis (D, H&E orig.
- Journal Article