Factors associated with age of onset and type of menopause in a cohort of UK women

Alida J. Pokoradi, Lisa Iversen, Philip C. Hannaford

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


OBJECTIVE: We sought to describe the pattern of age at menopause and factors associated with type of menopause.
STUDY DESIGN: This was a prospective cohort study of 5113 postmenopausal health survey respondents in the Royal College of General Practitioners’ Oral Contraception Study. Logistic regression was used to evaluate associations between sociodemographics, lifestyle, and medical history and menopause type.
RESULTS: Median age at natural menopause (n=3650) was 49.0 years (interquartile range, 45.0 –51.0), and at surgical menopause (n=1463) was 42.4 years (38.0 – 46.4). Early natural menopause was associated with smoking, ever-use of oral contraception, sterilization, and history of endometriosis (all increased odds ratios) and ever-use of hormone replacement therapy (decreased). Surgical menopause was associated with manual social class, sterilization, and having a history of endometriosis, menorrhagia, or painful menstruation (all increased), and ever-use of hormone replacement therapy (decreased).
CONCLUSION: Age at natural menopause was younger in this cohort than in other studies. More associations were found for surgical menopause than early natural menopause.
Original languageEnglish
Pages (from-to)34.e1-34.e13
Number of pages13
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
Early online date27 Feb 2011
Publication statusPublished - Jul 2011


  • age
  • menopause
  • natural menopause
  • onset
  • risk factors
  • surgical menopause


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