Factors associated with compliance to lipid-lowering treatment in China

Gaoqiang Xie, M Justin S Zaman, Phyo K Myint, Lirong Liang, Liancheng Zhao, Yangfeng Wu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: There are an estimated 200 million people in China with dyslipidaemia. We sought to explore factors that influence compliance to treatment of dyslipidaemia, using a multi-centre sample in China.
Methods: Through review of medical notes and direct interviews at two points in time (2006 and 2007) of 2094 patients in 27 hospitals receiving lipid-lowering therapy since 2004, 1890 patients were recruited who had been on treatment for more than one year. Good compliance (GC) was defined as days taking lipid-lowering drugs/total days of follow-up ≥80%. Logistic regression models were used to assess factors associated with GC.
Results: In patients with one, two and three years of treatment respectively, GC was greater in those with higher versus lower medical insurance cover – odds ratios 2.8 (95%CI 2.2–3.7), 2.0 (1.5–2.7), 4.3 (2.3–8.1); in patients in province-level versus county-level hospitals–2.0 (1.5–2.6), 2.9 (2.0–4.1), 4.6 (1.8–12.0); in patients treated by non-cardiology physicians compared to cardiologists −1.7 (1.1–2.5), 2.0 (1.3–3.0), 4.0 (1.5–10.3) and in patients using a statin versus other forms of medication for dyslipidaemia −1.7 (1.2–2.2), 1.7 (1.2–2.3), 4.4 (2.3–8.5).
Conclusions: Better medical insurance cover, care in a province-level hospital rather than county-level hospital, treatment by a non-cardiologist and use of a statin were associated with better compliance to lipid-lowering treatment.
Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalEuropean Journal of Preventive Cardiology
Issue number2
Early online date9 Feb 2012
Publication statusPublished - Apr 2013


  • aged
  • biological markers
  • chi-square distribution
  • China
  • delivery of health care
  • female
  • health knowledge, attitudes, practice
  • humans
  • hydroxymethylglutaryl-CoA reductase inhibitors
  • hyperlipidemias
  • hypolipidemic agents
  • insurance coverage
  • insurance, health
  • lipids
  • logistic models
  • male
  • medication adherence
  • middle aged
  • odds ratio
  • residence characteristics
  • risk factors
  • socioeconomic factors
  • time factors
  • treatment outcome
  • compliance
  • dyslipidaemia
  • lipid-lowering therapy
  • cardiovascular disease


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