Factors associated with compliance to lipid-lowering treatment in China

Gaoqiang Xie, M Justin S Zaman, Phyo K Myint, Lirong Liang, Liancheng Zhao, Yangfeng Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There are an estimated 200 million people in China with dyslipidaemia. We sought to explore factors that influence compliance to treatment of dyslipidaemia, using a multi-centre sample in China.
Methods: Through review of medical notes and direct interviews at two points in time (2006 and 2007) of 2094 patients in 27 hospitals receiving lipid-lowering therapy since 2004, 1890 patients were recruited who had been on treatment for more than one year. Good compliance (GC) was defined as days taking lipid-lowering drugs/total days of follow-up ≥80%. Logistic regression models were used to assess factors associated with GC.
Results: In patients with one, two and three years of treatment respectively, GC was greater in those with higher versus lower medical insurance cover – odds ratios 2.8 (95%CI 2.2–3.7), 2.0 (1.5–2.7), 4.3 (2.3–8.1); in patients in province-level versus county-level hospitals–2.0 (1.5–2.6), 2.9 (2.0–4.1), 4.6 (1.8–12.0); in patients treated by non-cardiology physicians compared to cardiologists −1.7 (1.1–2.5), 2.0 (1.3–3.0), 4.0 (1.5–10.3) and in patients using a statin versus other forms of medication for dyslipidaemia −1.7 (1.2–2.2), 1.7 (1.2–2.3), 4.4 (2.3–8.5).
Conclusions: Better medical insurance cover, care in a province-level hospital rather than county-level hospital, treatment by a non-cardiologist and use of a statin were associated with better compliance to lipid-lowering treatment.
Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalEuropean Journal of Preventive Cardiology
Volume20
Issue number2
Early online date9 Feb 2012
DOIs
Publication statusPublished - Apr 2013

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China
Lipids
Dyslipidemias
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Insurance
Therapeutics
Logistic Models
County Hospitals
Odds Ratio
Interviews
Physicians
Pharmaceutical Preparations

Keywords

  • aged
  • biological markers
  • chi-square distribution
  • China
  • delivery of health care
  • female
  • health knowledge, attitudes, practice
  • humans
  • hydroxymethylglutaryl-CoA reductase inhibitors
  • hyperlipidemias
  • hypolipidemic agents
  • insurance coverage
  • insurance, health
  • lipids
  • logistic models
  • male
  • medication adherence
  • middle aged
  • odds ratio
  • residence characteristics
  • risk factors
  • socioeconomic factors
  • time factors
  • treatment outcome
  • compliance
  • dyslipidaemia
  • lipid-lowering therapy
  • cardiovascular disease

Cite this

Factors associated with compliance to lipid-lowering treatment in China. / Xie, Gaoqiang; Zaman, M Justin S; Myint, Phyo K; Liang, Lirong; Zhao, Liancheng; Wu, Yangfeng.

In: European Journal of Preventive Cardiology, Vol. 20, No. 2, 04.2013, p. 229-237.

Research output: Contribution to journalArticle

Xie, Gaoqiang ; Zaman, M Justin S ; Myint, Phyo K ; Liang, Lirong ; Zhao, Liancheng ; Wu, Yangfeng. / Factors associated with compliance to lipid-lowering treatment in China. In: European Journal of Preventive Cardiology. 2013 ; Vol. 20, No. 2. pp. 229-237.
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abstract = "Background: There are an estimated 200 million people in China with dyslipidaemia. We sought to explore factors that influence compliance to treatment of dyslipidaemia, using a multi-centre sample in China.Methods: Through review of medical notes and direct interviews at two points in time (2006 and 2007) of 2094 patients in 27 hospitals receiving lipid-lowering therapy since 2004, 1890 patients were recruited who had been on treatment for more than one year. Good compliance (GC) was defined as days taking lipid-lowering drugs/total days of follow-up ≥80{\%}. Logistic regression models were used to assess factors associated with GC.Results: In patients with one, two and three years of treatment respectively, GC was greater in those with higher versus lower medical insurance cover – odds ratios 2.8 (95{\%}CI 2.2–3.7), 2.0 (1.5–2.7), 4.3 (2.3–8.1); in patients in province-level versus county-level hospitals–2.0 (1.5–2.6), 2.9 (2.0–4.1), 4.6 (1.8–12.0); in patients treated by non-cardiology physicians compared to cardiologists −1.7 (1.1–2.5), 2.0 (1.3–3.0), 4.0 (1.5–10.3) and in patients using a statin versus other forms of medication for dyslipidaemia −1.7 (1.2–2.2), 1.7 (1.2–2.3), 4.4 (2.3–8.5).Conclusions: Better medical insurance cover, care in a province-level hospital rather than county-level hospital, treatment by a non-cardiologist and use of a statin were associated with better compliance to lipid-lowering treatment.",
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AU - Xie, Gaoqiang

AU - Zaman, M Justin S

AU - Myint, Phyo K

AU - Liang, Lirong

AU - Zhao, Liancheng

AU - Wu, Yangfeng

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N2 - Background: There are an estimated 200 million people in China with dyslipidaemia. We sought to explore factors that influence compliance to treatment of dyslipidaemia, using a multi-centre sample in China.Methods: Through review of medical notes and direct interviews at two points in time (2006 and 2007) of 2094 patients in 27 hospitals receiving lipid-lowering therapy since 2004, 1890 patients were recruited who had been on treatment for more than one year. Good compliance (GC) was defined as days taking lipid-lowering drugs/total days of follow-up ≥80%. Logistic regression models were used to assess factors associated with GC.Results: In patients with one, two and three years of treatment respectively, GC was greater in those with higher versus lower medical insurance cover – odds ratios 2.8 (95%CI 2.2–3.7), 2.0 (1.5–2.7), 4.3 (2.3–8.1); in patients in province-level versus county-level hospitals–2.0 (1.5–2.6), 2.9 (2.0–4.1), 4.6 (1.8–12.0); in patients treated by non-cardiology physicians compared to cardiologists −1.7 (1.1–2.5), 2.0 (1.3–3.0), 4.0 (1.5–10.3) and in patients using a statin versus other forms of medication for dyslipidaemia −1.7 (1.2–2.2), 1.7 (1.2–2.3), 4.4 (2.3–8.5).Conclusions: Better medical insurance cover, care in a province-level hospital rather than county-level hospital, treatment by a non-cardiologist and use of a statin were associated with better compliance to lipid-lowering treatment.

AB - Background: There are an estimated 200 million people in China with dyslipidaemia. We sought to explore factors that influence compliance to treatment of dyslipidaemia, using a multi-centre sample in China.Methods: Through review of medical notes and direct interviews at two points in time (2006 and 2007) of 2094 patients in 27 hospitals receiving lipid-lowering therapy since 2004, 1890 patients were recruited who had been on treatment for more than one year. Good compliance (GC) was defined as days taking lipid-lowering drugs/total days of follow-up ≥80%. Logistic regression models were used to assess factors associated with GC.Results: In patients with one, two and three years of treatment respectively, GC was greater in those with higher versus lower medical insurance cover – odds ratios 2.8 (95%CI 2.2–3.7), 2.0 (1.5–2.7), 4.3 (2.3–8.1); in patients in province-level versus county-level hospitals–2.0 (1.5–2.6), 2.9 (2.0–4.1), 4.6 (1.8–12.0); in patients treated by non-cardiology physicians compared to cardiologists −1.7 (1.1–2.5), 2.0 (1.3–3.0), 4.0 (1.5–10.3) and in patients using a statin versus other forms of medication for dyslipidaemia −1.7 (1.2–2.2), 1.7 (1.2–2.3), 4.4 (2.3–8.5).Conclusions: Better medical insurance cover, care in a province-level hospital rather than county-level hospital, treatment by a non-cardiologist and use of a statin were associated with better compliance to lipid-lowering treatment.

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KW - biological markers

KW - chi-square distribution

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KW - delivery of health care

KW - female

KW - health knowledge, attitudes, practice

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KW - hydroxymethylglutaryl-CoA reductase inhibitors

KW - hyperlipidemias

KW - hypolipidemic agents

KW - insurance coverage

KW - insurance, health

KW - lipids

KW - logistic models

KW - male

KW - medication adherence

KW - middle aged

KW - odds ratio

KW - residence characteristics

KW - risk factors

KW - socioeconomic factors

KW - time factors

KW - treatment outcome

KW - compliance

KW - dyslipidaemia

KW - lipid-lowering therapy

KW - cardiovascular disease

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DO - 10.1177/2047487312438847

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VL - 20

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EP - 237

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

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