Abstract
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a malformation of the diaphragm accounting for 8% of all major congenital anomalies. While many clinical factors of survival in children with CDH have been established, there is a lack of knowledge on the role of sociodemographic factors. We aimed to systematically identify and summarise all available international literature, published from January 2000 to July 2017, evaluating specific mortality factors for children with prenatally-diagnosed, isolated, left-sided CDH.
METHODS: Relevant papers were identified by searching four databases and the table of contents for the past five years for relevant journals. The risk factors of interest were: birth weight, gestational age (GA) at diagnosis, GA at birth, infant sex, maternal age, ethnicity, socioeconomic status and plurality. The primary outcome measure was survival. Data were extracted on study design, study quality, participant data and survival-related effect estimates.
RESULTS: Seven studies fulfilled the inclusion criteria. Three were undertaken within Japan, three in USA and one in Czech Republic. GA at diagnosis and GA at birth were evaluated in six and five studies respectively, birth weight in four, infant sex in two and maternal age in one study. None of these factors showed a significant association with survival. No studies evaluated the influence of ethnicity, socioeconomic status or plurality.
CONCLUSION: Whilst the factors of interest showed no significant association with survival, more evidence is required to confirm these findings and potentially inform the development of public health interventions which can subsequently improve survival rates for CDH.
METHODS: Relevant papers were identified by searching four databases and the table of contents for the past five years for relevant journals. The risk factors of interest were: birth weight, gestational age (GA) at diagnosis, GA at birth, infant sex, maternal age, ethnicity, socioeconomic status and plurality. The primary outcome measure was survival. Data were extracted on study design, study quality, participant data and survival-related effect estimates.
RESULTS: Seven studies fulfilled the inclusion criteria. Three were undertaken within Japan, three in USA and one in Czech Republic. GA at diagnosis and GA at birth were evaluated in six and five studies respectively, birth weight in four, infant sex in two and maternal age in one study. None of these factors showed a significant association with survival. No studies evaluated the influence of ethnicity, socioeconomic status or plurality.
CONCLUSION: Whilst the factors of interest showed no significant association with survival, more evidence is required to confirm these findings and potentially inform the development of public health interventions which can subsequently improve survival rates for CDH.
Original language | English |
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Pages (from-to) | PF.026 |
Journal | BJOG-An International Journal of Obstetrics and Gynaecology |
Volume | 125 |
Issue number | S2 |
DOIs | |
Publication status | Published - Apr 2018 |
Event | British Maternal & Fetal Medicine Society (BMFMS) 20th Annual Conference 2018 - Brighton, UK Duration: 19 Apr 2018 → 20 Apr 2018 |