Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine

E.m. Johnstone, Sandra Murison, Sarah Duncan, K A Rance, John Roger Speakman

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

Background: Basal metabolic rate (BMR) is the largest component of daily energy demand in Western societies. Previous studies indicated that BMR is highly variable, but the cause of this variation is disputed. All studies agree that variation in fat-free mass (FFM) plays a major role, but effects of fat mass (FM), age, sex, and the hormones leptin, triiodothyrionine (T-3), and thyroxine (T-4) remain uncertain.

Objective: We partitioned the variance in BMR into within- and between-subject effects and explored the roles of FFM, FM, bone mineral content, sex, age, and circulating concentrations of plasma leptin, T-3, and T-4.

Design: This was a cross-sectional study of 150 white adults from northeast Scotland, United Kingdom.

Results: Only 2%of the observed variability in BMR was attributable to within-subject effects, of which 0.5% was analytic error. Of the remaining variance, which reflected between-subject effects, 63% was explained by FFM, 6% by FM, and 2% by age. The effects of sex and bone mineral content were not significant (P > 0.05). Twenty-six percent of the variance remained unexplained. This variation was not associated with concentrations of circulating leptin or T-3, T-4 was not significant in women but explained 25% of the residual variance in men.

Conclusions: Our data confirm that both FFM and FM are significant contributors to BMR. When the effect of FM on BMR is removed, any association with leptin concentrations disappears, which suggests that previous links between circulating leptin concentrations and BMR occurred only because of inadequate control for the effects of FM.

Original languageEnglish
Pages (from-to)941-948
Number of pages8
JournalThe American Journal of Clinical Nutrition
Volume82
Issue number5
Publication statusPublished - Nov 2005

Keywords

  • obesity
  • metabolism
  • hormones
  • health
  • body composition
  • resting energy-expenditure
  • respiratory exchange
  • serum-leptin
  • plasma leptin
  • chronic undernutrition
  • postmenopausal women
  • obese subjects
  • weight-gain
  • food-intake

Cite this

Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. / Johnstone, E.m.; Murison, Sandra; Duncan, Sarah; Rance, K A ; Speakman, John Roger.

In: The American Journal of Clinical Nutrition, Vol. 82, No. 5, 11.2005, p. 941-948.

Research output: Contribution to journalArticle

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abstract = "Background: Basal metabolic rate (BMR) is the largest component of daily energy demand in Western societies. Previous studies indicated that BMR is highly variable, but the cause of this variation is disputed. All studies agree that variation in fat-free mass (FFM) plays a major role, but effects of fat mass (FM), age, sex, and the hormones leptin, triiodothyrionine (T-3), and thyroxine (T-4) remain uncertain.Objective: We partitioned the variance in BMR into within- and between-subject effects and explored the roles of FFM, FM, bone mineral content, sex, age, and circulating concentrations of plasma leptin, T-3, and T-4.Design: This was a cross-sectional study of 150 white adults from northeast Scotland, United Kingdom.Results: Only 2{\%}of the observed variability in BMR was attributable to within-subject effects, of which 0.5{\%} was analytic error. Of the remaining variance, which reflected between-subject effects, 63{\%} was explained by FFM, 6{\%} by FM, and 2{\%} by age. The effects of sex and bone mineral content were not significant (P > 0.05). Twenty-six percent of the variance remained unexplained. This variation was not associated with concentrations of circulating leptin or T-3, T-4 was not significant in women but explained 25{\%} of the residual variance in men.Conclusions: Our data confirm that both FFM and FM are significant contributors to BMR. When the effect of FM on BMR is removed, any association with leptin concentrations disappears, which suggests that previous links between circulating leptin concentrations and BMR occurred only because of inadequate control for the effects of FM.",
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T1 - Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine

AU - Johnstone, E.m.

AU - Murison, Sandra

AU - Duncan, Sarah

AU - Rance, K A

AU - Speakman, John Roger

PY - 2005/11

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N2 - Background: Basal metabolic rate (BMR) is the largest component of daily energy demand in Western societies. Previous studies indicated that BMR is highly variable, but the cause of this variation is disputed. All studies agree that variation in fat-free mass (FFM) plays a major role, but effects of fat mass (FM), age, sex, and the hormones leptin, triiodothyrionine (T-3), and thyroxine (T-4) remain uncertain.Objective: We partitioned the variance in BMR into within- and between-subject effects and explored the roles of FFM, FM, bone mineral content, sex, age, and circulating concentrations of plasma leptin, T-3, and T-4.Design: This was a cross-sectional study of 150 white adults from northeast Scotland, United Kingdom.Results: Only 2%of the observed variability in BMR was attributable to within-subject effects, of which 0.5% was analytic error. Of the remaining variance, which reflected between-subject effects, 63% was explained by FFM, 6% by FM, and 2% by age. The effects of sex and bone mineral content were not significant (P > 0.05). Twenty-six percent of the variance remained unexplained. This variation was not associated with concentrations of circulating leptin or T-3, T-4 was not significant in women but explained 25% of the residual variance in men.Conclusions: Our data confirm that both FFM and FM are significant contributors to BMR. When the effect of FM on BMR is removed, any association with leptin concentrations disappears, which suggests that previous links between circulating leptin concentrations and BMR occurred only because of inadequate control for the effects of FM.

AB - Background: Basal metabolic rate (BMR) is the largest component of daily energy demand in Western societies. Previous studies indicated that BMR is highly variable, but the cause of this variation is disputed. All studies agree that variation in fat-free mass (FFM) plays a major role, but effects of fat mass (FM), age, sex, and the hormones leptin, triiodothyrionine (T-3), and thyroxine (T-4) remain uncertain.Objective: We partitioned the variance in BMR into within- and between-subject effects and explored the roles of FFM, FM, bone mineral content, sex, age, and circulating concentrations of plasma leptin, T-3, and T-4.Design: This was a cross-sectional study of 150 white adults from northeast Scotland, United Kingdom.Results: Only 2%of the observed variability in BMR was attributable to within-subject effects, of which 0.5% was analytic error. Of the remaining variance, which reflected between-subject effects, 63% was explained by FFM, 6% by FM, and 2% by age. The effects of sex and bone mineral content were not significant (P > 0.05). Twenty-six percent of the variance remained unexplained. This variation was not associated with concentrations of circulating leptin or T-3, T-4 was not significant in women but explained 25% of the residual variance in men.Conclusions: Our data confirm that both FFM and FM are significant contributors to BMR. When the effect of FM on BMR is removed, any association with leptin concentrations disappears, which suggests that previous links between circulating leptin concentrations and BMR occurred only because of inadequate control for the effects of FM.

KW - obesity

KW - metabolism

KW - hormones

KW - health

KW - body composition

KW - resting energy-expenditure

KW - respiratory exchange

KW - serum-leptin

KW - plasma leptin

KW - chronic undernutrition

KW - postmenopausal women

KW - obese subjects

KW - weight-gain

KW - food-intake

M3 - Article

VL - 82

SP - 941

EP - 948

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -