Abstract
The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.
| Original language | English |
|---|---|
| Pages (from-to) | 128-129 |
| Number of pages | 1 |
| Journal | Nature Genetics |
| Volume | 28 |
| DOIs | |
| Publication status | Published - Jun 2001 |
Keywords
- DEPENDENT DIABETES-MELLITUS
- INSULIN GENE
- LOCUS
- SUSCEPTIBILITY
Cite this
Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. / McGinnis, R. E.; Fox, Helen Catherine; Yates, P.; Cameron, L. A.; Barnes, Martine; Gray, I. C.; Spurr, N. K.; Hurko, O.; St Clair, David Malcolm.
In: Nature Genetics, Vol. 28, 06.2001, p. 128-129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland
AU - McGinnis, R. E.
AU - Fox, Helen Catherine
AU - Yates, P.
AU - Cameron, L. A.
AU - Barnes, Martine
AU - Gray, I. C.
AU - Spurr, N. K.
AU - Hurko, O.
AU - St Clair, David Malcolm
PY - 2001/6
Y1 - 2001/6
N2 - The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.
AB - The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.
KW - DEPENDENT DIABETES-MELLITUS
KW - INSULIN GENE
KW - LOCUS
KW - SUSCEPTIBILITY
U2 - 10.1038/88839
DO - 10.1038/88839
M3 - Article
VL - 28
SP - 128
EP - 129
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -