Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland

R. E. McGinnis; Helen Catherine Fox; P. Yates; L. A. Cameron; Martine Barnes; I. C. Gray; N. K. Spurr; O. Hurko; David Malcolm St Clair

doi:10.1038/88839

Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland

R. E. McGinnis, Helen Catherine Fox, P. Yates, L. A. Cameron, Martine Barnes, I. C. Gray, N. K. Spurr, O. Hurko, David Malcolm St Clair

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.

Original language	English
Pages (from-to)	128-129
Number of pages	1
Journal	Nature Genetics
Volume	28
DOIs	https://doi.org/10.1038/88839
Publication status	Published - Jun 2001

Keywords

DEPENDENT DIABETES-MELLITUS
INSULIN GENE
LOCUS
SUSCEPTIBILITY

Access to Document

10.1038/88839

Cite this

Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. / McGinnis, R. E.; Fox, Helen Catherine; Yates, P.; Cameron, L. A.; Barnes, Martine; Gray, I. C.; Spurr, N. K.; Hurko, O.; St Clair, David Malcolm.

In: Nature Genetics, Vol. 28, 06.2001, p. 128-129.

Research output: Contribution to journal › Article › peer-review

@article{87580243713c471a9706e7416bb9112e,

title = "Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland",

abstract = "The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.",

keywords = "DEPENDENT DIABETES-MELLITUS, INSULIN GENE, LOCUS, SUSCEPTIBILITY",

author = "McGinnis, {R. E.} and Fox, {Helen Catherine} and P. Yates and Cameron, {L. A.} and Martine Barnes and Gray, {I. C.} and Spurr, {N. K.} and O. Hurko and {St Clair}, {David Malcolm}",

year = "2001",

month = jun,

doi = "10.1038/88839",

language = "English",

volume = "28",

pages = "128--129",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland

AU - McGinnis, R. E.

AU - Fox, Helen Catherine

AU - Yates, P.

AU - Cameron, L. A.

AU - Barnes, Martine

AU - Gray, I. C.

AU - Spurr, N. K.

AU - Hurko, O.

AU - St Clair, David Malcolm

PY - 2001/6

Y1 - 2001/6

N2 - The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.

AB - The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.

KW - DEPENDENT DIABETES-MELLITUS

KW - INSULIN GENE

KW - LOCUS

KW - SUSCEPTIBILITY

U2 - 10.1038/88839

DO - 10.1038/88839

M3 - Article

VL - 28

SP - 128

EP - 129

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -