Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland

R. E. McGinnis, Helen Catherine Fox, P. Yates, L. A. Cameron, Martine Barnes, I. C. Gray, N. K. Spurr, O. Hurko, David Malcolm St Clair

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Abstract

The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.

Original languageEnglish
Pages (from-to)128-129
Number of pages1
JournalNature Genetics
Volume28
DOIs
Publication statusPublished - Jun 2001

Keywords

  • DEPENDENT DIABETES-MELLITUS
  • INSULIN GENE
  • LOCUS
  • SUSCEPTIBILITY

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