Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland

R. E. McGinnis; Helen Catherine Fox; P. Yates; L. A. Cameron; Martine Barnes; I. C. Gray; N. K. Spurr; O. Hurko; David Malcolm St Clair

doi:10.1038/88839

Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland

R. E. McGinnis, Helen Catherine Fox, P. Yates, L. A. Cameron, Martine Barnes, I. C. Gray, N. K. Spurr, O. Hurko, David Malcolm St Clair

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45 Citations (Scopus)

Abstract

The NOTCH4 gene was recently reported to be associated with schizophrenia(1) based on TDT analysis of 80 British trios. The strongest evidence for association derived from two microsatellites. We genotyped both loci in a large sample of unrelated Scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls.

Original language	English
Pages (from-to)	128-129
Number of pages	1
Journal	Nature Genetics
Volume	28
DOIs	https://doi.org/10.1038/88839
Publication status	Published - Jun 2001

Keywords

DEPENDENT DIABETES-MELLITUS
INSULIN GENE
LOCUS
SUSCEPTIBILITY

Cite this

McGinnis, R. E., Fox, H. C., Yates, P., Cameron, L. A., Barnes, M., Gray, I. C., ... St Clair, D. M. (2001). Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nature Genetics, 28, 128-129. https://doi.org/10.1038/88839

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10.1038/88839