Familial cold urticaria. Investigation of a family and response to stanozolol

Anthony Ormerod, Louise Smart, Thomas Reid, A Milford-Ward

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42 Citations (Scopus)


BACKGROUND: Familial cold urticaria is a rare cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown pathogenesis. Release of a chymotrypsinlike substance has been postulated. To date, no effective treatment has been reported. OBSERVATIONS: Eight cases from a large family pedigree are described. Three members showed a very favorable response in their cold urticaria, when treated with stanozolol; the response was reproducible. Histologic examination of an early lesion in one case revealed evidence of mast cell degranulation. CONCLUSIONS: The biochemical observations are probably secondary epiphenomena. Correction of a deficiency of an inhibitory protein is a possible mechanism of action of stanozolol as in hereditary angioedema.
Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalArchives of Dermatology
Issue number3
Publication statusPublished - 1 Mar 1993


  • Adult
  • Cold Temperature
  • Esterases
  • Female
  • Humans
  • Middle Aged
  • Pedigree
  • Stanozolol
  • Urticaria


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