Familial cold urticaria. Investigation of a family and response to stanozolol

Anthony Ormerod, Louise Smart, Thomas Reid, A Milford-Ward

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

BACKGROUND: Familial cold urticaria is a rare cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown pathogenesis. Release of a chymotrypsinlike substance has been postulated. To date, no effective treatment has been reported. OBSERVATIONS: Eight cases from a large family pedigree are described. Three members showed a very favorable response in their cold urticaria, when treated with stanozolol; the response was reproducible. Histologic examination of an early lesion in one case revealed evidence of mast cell degranulation. CONCLUSIONS: The biochemical observations are probably secondary epiphenomena. Correction of a deficiency of an inhibitory protein is a possible mechanism of action of stanozolol as in hereditary angioedema.
Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalArchives of Dermatology
Volume129
Issue number3
Publication statusPublished - 1 Mar 1993

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Stanozolol
Cryopyrin-Associated Periodic Syndromes
Hereditary Angioedemas
Cell Degranulation
Protein Deficiency
Urticaria
Pedigree
Mast Cells
Skin

Keywords

  • Adult
  • Cold Temperature
  • Esterases
  • Female
  • Humans
  • Middle Aged
  • Pedigree
  • Stanozolol
  • Urticaria

Cite this

Familial cold urticaria. Investigation of a family and response to stanozolol. / Ormerod, Anthony; Smart, Louise; Reid, Thomas; Milford-Ward, A.

In: Archives of Dermatology, Vol. 129, No. 3, 01.03.1993, p. 343-346.

Research output: Contribution to journalArticle

Ormerod, A, Smart, L, Reid, T & Milford-Ward, A 1993, 'Familial cold urticaria. Investigation of a family and response to stanozolol', Archives of Dermatology, vol. 129, no. 3, pp. 343-346.
Ormerod, Anthony ; Smart, Louise ; Reid, Thomas ; Milford-Ward, A. / Familial cold urticaria. Investigation of a family and response to stanozolol. In: Archives of Dermatology. 1993 ; Vol. 129, No. 3. pp. 343-346.
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AB - BACKGROUND: Familial cold urticaria is a rare cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown pathogenesis. Release of a chymotrypsinlike substance has been postulated. To date, no effective treatment has been reported. OBSERVATIONS: Eight cases from a large family pedigree are described. Three members showed a very favorable response in their cold urticaria, when treated with stanozolol; the response was reproducible. Histologic examination of an early lesion in one case revealed evidence of mast cell degranulation. CONCLUSIONS: The biochemical observations are probably secondary epiphenomena. Correction of a deficiency of an inhibitory protein is a possible mechanism of action of stanozolol as in hereditary angioedema.

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