Fast field-cycling magnetic resonance imaging

David J Lurie, Silvio Aime, Simona Baroni, Nuala Booth, Lionel Broche, Chang-Hoon Choi, Gareth R Davies, Saadiya Ismail, Dara O Hogain, Kerrin J Pine

Research output: Contribution to journalArticlepeer-review


Magnetic resonance imaging (MRI) and fast field-cycling (FFC) NMR are both well-developed methods. The combination of these techniques, namely fast field-cycling magnetic resonance imaging (FFC-MRI) is much less well-known. Nevertheless, FFC-MRI has a number of significant applications and advantages over conventional techniques, and is being pursued in a number of laboratories. This article reviews the progress in FFC-MRI over the last two decades, particularly in the areas of Earth's field and pre-polarised MRI, as well as free radical imaging using field-cycling Overhauser MRI. Different approaches to magnet design for FFC-MRI are also described. The paper then goes on to discuss recent techniques and applications of FFC-MRI, including protein measurement via quadrupolar cross-relaxation, contrast agent studies, localised relaxometry and FFC-MRI with magnetisation-transfer contrast.
Original languageEnglish
Pages (from-to)136-148
Number of pages13
JournalComptes Rendus. Physique
Issue number2
Publication statusPublished - Mar 2010


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