Fatal disseminated Cryptococcus gattii infection in New Mexico

Carla J Walraven, Wendy Gerstein, Sarah E Hardison, Floyd Wormley, Shawn R Lockhart, Julie R Harris, Annette Fothergill, Brian Wickes, Julie Gober-Wilcox, Larry Massie, T S Neil Ku, Carolina Firacative, Wieland Meyer, Samuel A Lee

Research output: Contribution to journalArticle

27 Citations (Scopus)
4 Downloads (Pure)

Abstract

We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

Original languageEnglish
Article numbere28625
Number of pages8
JournalPloS ONE
Volume6
Issue number12
DOIs
Publication statusPublished - 14 Dec 2011

Fingerprint

Cryptococcus gattii
Infection
infection
Multilocus Sequence Typing
travel
Virulence
virulence
lungs
case studies
Lung
mice

Cite this

Walraven, C. J., Gerstein, W., Hardison, S. E., Wormley, F., Lockhart, S. R., Harris, J. R., ... A Lee, S. (2011). Fatal disseminated Cryptococcus gattii infection in New Mexico. PloS ONE, 6(12), [e28625]. https://doi.org/10.1371/journal.pone.0028625

Fatal disseminated Cryptococcus gattii infection in New Mexico. / Walraven, Carla J; Gerstein, Wendy; Hardison, Sarah E; Wormley, Floyd; Lockhart, Shawn R; Harris, Julie R; Fothergill, Annette; Wickes, Brian; Gober-Wilcox, Julie; Massie, Larry; Ku, T S Neil; Firacative, Carolina; Meyer, Wieland; A Lee, Samuel.

In: PloS ONE, Vol. 6, No. 12, e28625, 14.12.2011.

Research output: Contribution to journalArticle

Walraven, CJ, Gerstein, W, Hardison, SE, Wormley, F, Lockhart, SR, Harris, JR, Fothergill, A, Wickes, B, Gober-Wilcox, J, Massie, L, Ku, TSN, Firacative, C, Meyer, W & A Lee, S 2011, 'Fatal disseminated Cryptococcus gattii infection in New Mexico', PloS ONE, vol. 6, no. 12, e28625. https://doi.org/10.1371/journal.pone.0028625
Walraven CJ, Gerstein W, Hardison SE, Wormley F, Lockhart SR, Harris JR et al. Fatal disseminated Cryptococcus gattii infection in New Mexico. PloS ONE. 2011 Dec 14;6(12). e28625. https://doi.org/10.1371/journal.pone.0028625
Walraven, Carla J ; Gerstein, Wendy ; Hardison, Sarah E ; Wormley, Floyd ; Lockhart, Shawn R ; Harris, Julie R ; Fothergill, Annette ; Wickes, Brian ; Gober-Wilcox, Julie ; Massie, Larry ; Ku, T S Neil ; Firacative, Carolina ; Meyer, Wieland ; A Lee, Samuel. / Fatal disseminated Cryptococcus gattii infection in New Mexico. In: PloS ONE. 2011 ; Vol. 6, No. 12.
@article{b1d9dac7b0654cbf84605f19131d3263,
title = "Fatal disseminated Cryptococcus gattii infection in New Mexico",
abstract = "We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.",
author = "Walraven, {Carla J} and Wendy Gerstein and Hardison, {Sarah E} and Floyd Wormley and Lockhart, {Shawn R} and Harris, {Julie R} and Annette Fothergill and Brian Wickes and Julie Gober-Wilcox and Larry Massie and Ku, {T S Neil} and Carolina Firacative and Wieland Meyer and {A Lee}, Samuel",
year = "2011",
month = "12",
day = "14",
doi = "10.1371/journal.pone.0028625",
language = "English",
volume = "6",
journal = "PloS ONE",
issn = "1932-6203",
publisher = "PUBLIC LIBRARY SCIENCE",
number = "12",

}

TY - JOUR

T1 - Fatal disseminated Cryptococcus gattii infection in New Mexico

AU - Walraven, Carla J

AU - Gerstein, Wendy

AU - Hardison, Sarah E

AU - Wormley, Floyd

AU - Lockhart, Shawn R

AU - Harris, Julie R

AU - Fothergill, Annette

AU - Wickes, Brian

AU - Gober-Wilcox, Julie

AU - Massie, Larry

AU - Ku, T S Neil

AU - Firacative, Carolina

AU - Meyer, Wieland

AU - A Lee, Samuel

PY - 2011/12/14

Y1 - 2011/12/14

N2 - We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

AB - We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

U2 - 10.1371/journal.pone.0028625

DO - 10.1371/journal.pone.0028625

M3 - Article

VL - 6

JO - PloS ONE

JF - PloS ONE

SN - 1932-6203

IS - 12

M1 - e28625

ER -