Fatal disseminated Cryptococcus gattii infection in New Mexico

Carla J Walraven, Wendy Gerstein, Sarah E Hardison, Floyd Wormley, Shawn R Lockhart, Julie R Harris, Annette Fothergill, Brian Wickes, Julie Gober-Wilcox, Larry Massie, T S Neil Ku, Carolina Firacative, Wieland Meyer, Samuel A Lee

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Abstract

We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

Original languageEnglish
Article numbere28625
Number of pages8
JournalPloS ONE
Volume6
Issue number12
DOIs
Publication statusPublished - 14 Dec 2011

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  • Cite this

    Walraven, C. J., Gerstein, W., Hardison, S. E., Wormley, F., Lockhart, S. R., Harris, J. R., Fothergill, A., Wickes, B., Gober-Wilcox, J., Massie, L., Ku, T. S. N., Firacative, C., Meyer, W., & A Lee, S. (2011). Fatal disseminated Cryptococcus gattii infection in New Mexico. PloS ONE, 6(12), [e28625]. https://doi.org/10.1371/journal.pone.0028625