Fatigue

A principal contributor to impaired quality of life in ANCA-associated vasculitis

Neil Basu, Gareth Jones, Nick Fluck, Alan G. MacDonald, Dong Pang, Paula Dospinescu, David M Reid, Gary Macfarlane

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objectives. To describe quality of life (QoL) in an ANCA-associated vasculitis (AAV) cohort and make comparisons with a general population sample. In addition, we aimed to take preliminary steps to identify potential disease and psycho-social factors which may determine QoL impairment.
Methods. A population-based case–control study was designed. All AAV patients resident in Grampian, Scotland, were invited to participate as cases. Controls were identified from a random sample of persons registered with four local general practices. Participants completed a questionnaire comprising validated generic and symptom-specific tools in the assessment of QoL. In addition, all cases were clinically assessed and putative disease factors recorded. Cases and controls were compared and, in addition, disease and psycho-social associations were explored for identified QoL impairments.
Results. In total, 74/90 (82%) cases and 781/2000 (39%) controls participated. Cases reported a significant impairment in physical health (P < 0.0001), but not mental health (P = 0.85), compared with controls, as measured by Short Form-8 (SF-8). Following adjustment for age and sex, persons with AAV were more than twice as likely to report mild/moderate fatigue [odds ratio (OR) 2.0; 95% CI 1.1, 3.8] or severe fatigue (OR 2.5; 95% CI 1.4, 4.5) compared with controls. Furthermore, among cases, fatigue was found to be strongly associated with impaired physical health (P < 0.0001), while disease factors such as disease activity and damage were not (P = 0.60 and 0.27, respectively).
Conclusions. Patients with AAV report impaired physical but not mental health. Specifically, fatigue is a principal complaint and appears to be a major determinant of impaired QoL.
Original languageEnglish
Pages (from-to)1383-1390
Number of pages8
JournalRheumatology
Volume49
Issue number7
Early online date17 Apr 2010
DOIs
Publication statusPublished - Jul 2010

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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Fatigue
Quality of Life
Mental Health
Odds Ratio
Health
Scotland
General Practice
Population

Keywords

  • ANCA-associated vasculitis
  • Wegener's granulomatosis
  • microscopic polyangiitis
  • Churg-Strauss syndrome
  • vasculitis
  • quality of life
  • fatigue

Cite this

Fatigue : A principal contributor to impaired quality of life in ANCA-associated vasculitis. / Basu, Neil; Jones, Gareth; Fluck, Nick; MacDonald, Alan G.; Pang, Dong; Dospinescu, Paula; Reid, David M; Macfarlane, Gary.

In: Rheumatology, Vol. 49, No. 7, 07.2010, p. 1383-1390.

Research output: Contribution to journalArticle

Basu, Neil ; Jones, Gareth ; Fluck, Nick ; MacDonald, Alan G. ; Pang, Dong ; Dospinescu, Paula ; Reid, David M ; Macfarlane, Gary. / Fatigue : A principal contributor to impaired quality of life in ANCA-associated vasculitis. In: Rheumatology. 2010 ; Vol. 49, No. 7. pp. 1383-1390.
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abstract = "Objectives. To describe quality of life (QoL) in an ANCA-associated vasculitis (AAV) cohort and make comparisons with a general population sample. In addition, we aimed to take preliminary steps to identify potential disease and psycho-social factors which may determine QoL impairment. Methods. A population-based case–control study was designed. All AAV patients resident in Grampian, Scotland, were invited to participate as cases. Controls were identified from a random sample of persons registered with four local general practices. Participants completed a questionnaire comprising validated generic and symptom-specific tools in the assessment of QoL. In addition, all cases were clinically assessed and putative disease factors recorded. Cases and controls were compared and, in addition, disease and psycho-social associations were explored for identified QoL impairments. Results. In total, 74/90 (82{\%}) cases and 781/2000 (39{\%}) controls participated. Cases reported a significant impairment in physical health (P < 0.0001), but not mental health (P = 0.85), compared with controls, as measured by Short Form-8 (SF-8). Following adjustment for age and sex, persons with AAV were more than twice as likely to report mild/moderate fatigue [odds ratio (OR) 2.0; 95{\%} CI 1.1, 3.8] or severe fatigue (OR 2.5; 95{\%} CI 1.4, 4.5) compared with controls. Furthermore, among cases, fatigue was found to be strongly associated with impaired physical health (P < 0.0001), while disease factors such as disease activity and damage were not (P = 0.60 and 0.27, respectively). Conclusions. Patients with AAV report impaired physical but not mental health. Specifically, fatigue is a principal complaint and appears to be a major determinant of impaired QoL.",
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AU - Basu, Neil

AU - Jones, Gareth

AU - Fluck, Nick

AU - MacDonald, Alan G.

AU - Pang, Dong

AU - Dospinescu, Paula

AU - Reid, David M

AU - Macfarlane, Gary

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N2 - Objectives. To describe quality of life (QoL) in an ANCA-associated vasculitis (AAV) cohort and make comparisons with a general population sample. In addition, we aimed to take preliminary steps to identify potential disease and psycho-social factors which may determine QoL impairment. Methods. A population-based case–control study was designed. All AAV patients resident in Grampian, Scotland, were invited to participate as cases. Controls were identified from a random sample of persons registered with four local general practices. Participants completed a questionnaire comprising validated generic and symptom-specific tools in the assessment of QoL. In addition, all cases were clinically assessed and putative disease factors recorded. Cases and controls were compared and, in addition, disease and psycho-social associations were explored for identified QoL impairments. Results. In total, 74/90 (82%) cases and 781/2000 (39%) controls participated. Cases reported a significant impairment in physical health (P < 0.0001), but not mental health (P = 0.85), compared with controls, as measured by Short Form-8 (SF-8). Following adjustment for age and sex, persons with AAV were more than twice as likely to report mild/moderate fatigue [odds ratio (OR) 2.0; 95% CI 1.1, 3.8] or severe fatigue (OR 2.5; 95% CI 1.4, 4.5) compared with controls. Furthermore, among cases, fatigue was found to be strongly associated with impaired physical health (P < 0.0001), while disease factors such as disease activity and damage were not (P = 0.60 and 0.27, respectively). Conclusions. Patients with AAV report impaired physical but not mental health. Specifically, fatigue is a principal complaint and appears to be a major determinant of impaired QoL.

AB - Objectives. To describe quality of life (QoL) in an ANCA-associated vasculitis (AAV) cohort and make comparisons with a general population sample. In addition, we aimed to take preliminary steps to identify potential disease and psycho-social factors which may determine QoL impairment. Methods. A population-based case–control study was designed. All AAV patients resident in Grampian, Scotland, were invited to participate as cases. Controls were identified from a random sample of persons registered with four local general practices. Participants completed a questionnaire comprising validated generic and symptom-specific tools in the assessment of QoL. In addition, all cases were clinically assessed and putative disease factors recorded. Cases and controls were compared and, in addition, disease and psycho-social associations were explored for identified QoL impairments. Results. In total, 74/90 (82%) cases and 781/2000 (39%) controls participated. Cases reported a significant impairment in physical health (P < 0.0001), but not mental health (P = 0.85), compared with controls, as measured by Short Form-8 (SF-8). Following adjustment for age and sex, persons with AAV were more than twice as likely to report mild/moderate fatigue [odds ratio (OR) 2.0; 95% CI 1.1, 3.8] or severe fatigue (OR 2.5; 95% CI 1.4, 4.5) compared with controls. Furthermore, among cases, fatigue was found to be strongly associated with impaired physical health (P < 0.0001), while disease factors such as disease activity and damage were not (P = 0.60 and 0.27, respectively). Conclusions. Patients with AAV report impaired physical but not mental health. Specifically, fatigue is a principal complaint and appears to be a major determinant of impaired QoL.

KW - ANCA-associated vasculitis

KW - Wegener's granulomatosis

KW - microscopic polyangiitis

KW - Churg-Strauss syndrome

KW - vasculitis

KW - quality of life

KW - fatigue

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DO - 10.1093/rheumatology/keq098

M3 - Article

VL - 49

SP - 1383

EP - 1390

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 7

ER -