Favorable Outcome of Neonatal Cerebrospinal Fluid Shunt-Associated Candida Meningitis with Caspofungin

Jop Jans, Roger J. M. Brüggemann, V. Christmann, Paul E. Verweij, Adilia Warris

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.

Original languageEnglish
Pages (from-to)2391-2393
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number5
Early online date25 Feb 2013
DOIs
Publication statusPublished - May 2013

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caspofungin
Cerebrospinal Fluid Shunts
Candida
Meningitis
Device Removal
Equipment and Supplies
Infection
Cerebrospinal Fluid
Pharmacokinetics

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Favorable Outcome of Neonatal Cerebrospinal Fluid Shunt-Associated Candida Meningitis with Caspofungin. / Jans, Jop; Brüggemann, Roger J. M.; Christmann, V.; Verweij, Paul E.; Warris, Adilia.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 5, 05.2013, p. 2391-2393.

Research output: Contribution to journalArticle

Jans, Jop ; Brüggemann, Roger J. M. ; Christmann, V. ; Verweij, Paul E. ; Warris, Adilia. / Favorable Outcome of Neonatal Cerebrospinal Fluid Shunt-Associated Candida Meningitis with Caspofungin. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 5. pp. 2391-2393.
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