Female mice respond differently to costly foraging versus food restriction

Kristin A Schubert, Lobke Maria Vaanholt, Fanny Stavasius, Gregory E Demas, Serge Daan, G Henk Visser

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Experimental manipulation of foraging costs per food reward can be used to study the plasticity of physiological systems involved in energy metabolism. This approach is useful for understanding adaptations to natural variation in food availability. Earlier studies have shown that animals foraging on a fixed reward schedule decrease energy intake and expenditure. However, the extent to which these changes depend on decreased food intake or increased foraging costs per se has never been tested. We manipulated foraging costs per food reward in female Hsd:ICR(CD-1) laboratory mice, comparing animals faced with low (L) and high (H) foraging costs to non-foraging animals receiving a food restriction (R) matched to the intake of H animals. Mice in the H group ran as much as L mice did but ate significantly less. They concurrently reduced daily energy expenditure and resting metabolic rate, decreased the size of major metabolic organs and utilized body fat stores; mass-specific resting metabolic rate did not differ between groups. We found evidence that these alterations in energy balance may carry fitness costs. As a secondary response to our experimental treatment, H females and, eventually, some R females ceased to show signs of estrous cyclicity. Surprisingly, results of an immune challenge with keyhole limpet hemocyanin showed that primary immune response did not differ between L and H groups, and was actually higher in R mice. Our results demonstrate that high foraging costs per se--the combination of high activity and low food intake--have pronounced physiological effects in female mice.
Original languageEnglish
Pages (from-to)2214-2223
Number of pages10
JournalJournal of Experimental Biology
Volume211
Issue number14
Early online date27 Jun 2008
DOIs
Publication statusPublished - 15 Jul 2008

Fingerprint

foraging
Costs and Cost Analysis
Food
food
mice
Reward
cost
Energy Metabolism
Basal Metabolism
resting metabolic rate
animal
food intake
energy expenditure
expenditure
Eating
energy
animals
cyclicity
Periodicity
food animals

Keywords

  • animals
  • body composition
  • eating
  • energy metabolism
  • estrous cycle
  • feeding behavior
  • female
  • hemocyanin
  • immunocompetence
  • mice
  • mice, inbred ICR
  • foraging costs
  • food restriction
  • workload
  • daily energy expenditure (DEE)
  • resting metabolic rate (RMR)
  • allocation trade-offs

Cite this

Schubert, K. A., Vaanholt, L. M., Stavasius, F., Demas, G. E., Daan, S., & Visser, G. H. (2008). Female mice respond differently to costly foraging versus food restriction. Journal of Experimental Biology, 211(14), 2214-2223. https://doi.org/10.1242/jeb.017525

Female mice respond differently to costly foraging versus food restriction. / Schubert, Kristin A; Vaanholt, Lobke Maria; Stavasius, Fanny; Demas, Gregory E; Daan, Serge; Visser, G Henk.

In: Journal of Experimental Biology, Vol. 211, No. 14, 15.07.2008, p. 2214-2223.

Research output: Contribution to journalArticle

Schubert, KA, Vaanholt, LM, Stavasius, F, Demas, GE, Daan, S & Visser, GH 2008, 'Female mice respond differently to costly foraging versus food restriction', Journal of Experimental Biology, vol. 211, no. 14, pp. 2214-2223. https://doi.org/10.1242/jeb.017525
Schubert KA, Vaanholt LM, Stavasius F, Demas GE, Daan S, Visser GH. Female mice respond differently to costly foraging versus food restriction. Journal of Experimental Biology. 2008 Jul 15;211(14):2214-2223. https://doi.org/10.1242/jeb.017525
Schubert, Kristin A ; Vaanholt, Lobke Maria ; Stavasius, Fanny ; Demas, Gregory E ; Daan, Serge ; Visser, G Henk. / Female mice respond differently to costly foraging versus food restriction. In: Journal of Experimental Biology. 2008 ; Vol. 211, No. 14. pp. 2214-2223.
@article{29f3a00b9ac7463b8519560b21951a7d,
title = "Female mice respond differently to costly foraging versus food restriction",
abstract = "Experimental manipulation of foraging costs per food reward can be used to study the plasticity of physiological systems involved in energy metabolism. This approach is useful for understanding adaptations to natural variation in food availability. Earlier studies have shown that animals foraging on a fixed reward schedule decrease energy intake and expenditure. However, the extent to which these changes depend on decreased food intake or increased foraging costs per se has never been tested. We manipulated foraging costs per food reward in female Hsd:ICR(CD-1) laboratory mice, comparing animals faced with low (L) and high (H) foraging costs to non-foraging animals receiving a food restriction (R) matched to the intake of H animals. Mice in the H group ran as much as L mice did but ate significantly less. They concurrently reduced daily energy expenditure and resting metabolic rate, decreased the size of major metabolic organs and utilized body fat stores; mass-specific resting metabolic rate did not differ between groups. We found evidence that these alterations in energy balance may carry fitness costs. As a secondary response to our experimental treatment, H females and, eventually, some R females ceased to show signs of estrous cyclicity. Surprisingly, results of an immune challenge with keyhole limpet hemocyanin showed that primary immune response did not differ between L and H groups, and was actually higher in R mice. Our results demonstrate that high foraging costs per se--the combination of high activity and low food intake--have pronounced physiological effects in female mice.",
keywords = "animals, body composition, eating, energy metabolism, estrous cycle, feeding behavior, female , hemocyanin, immunocompetence, mice, mice, inbred ICR, foraging costs, food restriction, workload, daily energy expenditure (DEE), resting metabolic rate (RMR), allocation trade-offs",
author = "Schubert, {Kristin A} and Vaanholt, {Lobke Maria} and Fanny Stavasius and Demas, {Gregory E} and Serge Daan and Visser, {G Henk}",
year = "2008",
month = "7",
day = "15",
doi = "10.1242/jeb.017525",
language = "English",
volume = "211",
pages = "2214--2223",
journal = "Journal of Experimental Biology",
issn = "0022-0949",
publisher = "Company of Biologists Ltd",
number = "14",

}

TY - JOUR

T1 - Female mice respond differently to costly foraging versus food restriction

AU - Schubert, Kristin A

AU - Vaanholt, Lobke Maria

AU - Stavasius, Fanny

AU - Demas, Gregory E

AU - Daan, Serge

AU - Visser, G Henk

PY - 2008/7/15

Y1 - 2008/7/15

N2 - Experimental manipulation of foraging costs per food reward can be used to study the plasticity of physiological systems involved in energy metabolism. This approach is useful for understanding adaptations to natural variation in food availability. Earlier studies have shown that animals foraging on a fixed reward schedule decrease energy intake and expenditure. However, the extent to which these changes depend on decreased food intake or increased foraging costs per se has never been tested. We manipulated foraging costs per food reward in female Hsd:ICR(CD-1) laboratory mice, comparing animals faced with low (L) and high (H) foraging costs to non-foraging animals receiving a food restriction (R) matched to the intake of H animals. Mice in the H group ran as much as L mice did but ate significantly less. They concurrently reduced daily energy expenditure and resting metabolic rate, decreased the size of major metabolic organs and utilized body fat stores; mass-specific resting metabolic rate did not differ between groups. We found evidence that these alterations in energy balance may carry fitness costs. As a secondary response to our experimental treatment, H females and, eventually, some R females ceased to show signs of estrous cyclicity. Surprisingly, results of an immune challenge with keyhole limpet hemocyanin showed that primary immune response did not differ between L and H groups, and was actually higher in R mice. Our results demonstrate that high foraging costs per se--the combination of high activity and low food intake--have pronounced physiological effects in female mice.

AB - Experimental manipulation of foraging costs per food reward can be used to study the plasticity of physiological systems involved in energy metabolism. This approach is useful for understanding adaptations to natural variation in food availability. Earlier studies have shown that animals foraging on a fixed reward schedule decrease energy intake and expenditure. However, the extent to which these changes depend on decreased food intake or increased foraging costs per se has never been tested. We manipulated foraging costs per food reward in female Hsd:ICR(CD-1) laboratory mice, comparing animals faced with low (L) and high (H) foraging costs to non-foraging animals receiving a food restriction (R) matched to the intake of H animals. Mice in the H group ran as much as L mice did but ate significantly less. They concurrently reduced daily energy expenditure and resting metabolic rate, decreased the size of major metabolic organs and utilized body fat stores; mass-specific resting metabolic rate did not differ between groups. We found evidence that these alterations in energy balance may carry fitness costs. As a secondary response to our experimental treatment, H females and, eventually, some R females ceased to show signs of estrous cyclicity. Surprisingly, results of an immune challenge with keyhole limpet hemocyanin showed that primary immune response did not differ between L and H groups, and was actually higher in R mice. Our results demonstrate that high foraging costs per se--the combination of high activity and low food intake--have pronounced physiological effects in female mice.

KW - animals

KW - body composition

KW - eating

KW - energy metabolism

KW - estrous cycle

KW - feeding behavior

KW - female

KW - hemocyanin

KW - immunocompetence

KW - mice

KW - mice, inbred ICR

KW - foraging costs

KW - food restriction

KW - workload

KW - daily energy expenditure (DEE)

KW - resting metabolic rate (RMR)

KW - allocation trade-offs

U2 - 10.1242/jeb.017525

DO - 10.1242/jeb.017525

M3 - Article

C2 - 18587115

VL - 211

SP - 2214

EP - 2223

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

SN - 0022-0949

IS - 14

ER -