TY - JOUR
T1 - Fetal fibronectin status and cervical length in women with threatened preterm labor and the effectiveness of maintenance tocolysis
AU - Roos, Carolien
AU - Vis, Jolande Y.
AU - Scheepers, Hubertina C.J.
AU - Bloemenkamp, Kitty W.M.
AU - Duvekot, Hans J.J.
AU - Van Eyck, Jim
AU - De Groot, Christianne
AU - Kok, Joke H.
AU - Opmeer, Brent C.
AU - Oudijk, Martijn A.
AU - Papatsonis, Dimitri N.M.
AU - Porath, Martina M.
AU - Sollie, Krystyna
AU - Spaanderman, Marc E.A.
AU - Lotgering, Fred K.
AU - Van Der Post, Joris A.M.
AU - Mol, Ben Willem J.
PY - 2016
Y1 - 2016
N2 - Objective: To assess the effect of maintenance tocolysis in women who are at high or low risk for preterm delivery according to fetal fibronectin (fFN) status and cervical length (CL).Study design: We compared the risk of preterm delivery in fFN pos and fFN neg women and in women with a CL <15 mm and ≥15 mm, by using the Cox regression. Differences between the effectiveness of maintenance tocolysis in high- and low-risk women were assessed by using an interaction term.Results: 122 fFN tests were taken, of which 50 were fFN pos. CL was measured in 236 women, of whom 52 women had a CL <15 mm. The median gestational age at delivery was lower in fFN pos women; fFN pos women had a higher hazard for preterm delivery at any point of time (HR 4.7; 95% CI 2.9 to 7.6). Comparable results were seen for CL. Neither fFN status nor CL did alter the effect of maintenance tocolysis, which was ineffective in the total randomized group, on the risk of preterm delivery (p for interaction = 0.87 for fFN and 0.18 for CL).Conclusion: Maintenance tocolytic therapy with nifedipine is ineffective and not dependent on fFN or CL status.
AB - Objective: To assess the effect of maintenance tocolysis in women who are at high or low risk for preterm delivery according to fetal fibronectin (fFN) status and cervical length (CL).Study design: We compared the risk of preterm delivery in fFN pos and fFN neg women and in women with a CL <15 mm and ≥15 mm, by using the Cox regression. Differences between the effectiveness of maintenance tocolysis in high- and low-risk women were assessed by using an interaction term.Results: 122 fFN tests were taken, of which 50 were fFN pos. CL was measured in 236 women, of whom 52 women had a CL <15 mm. The median gestational age at delivery was lower in fFN pos women; fFN pos women had a higher hazard for preterm delivery at any point of time (HR 4.7; 95% CI 2.9 to 7.6). Comparable results were seen for CL. Neither fFN status nor CL did alter the effect of maintenance tocolysis, which was ineffective in the total randomized group, on the risk of preterm delivery (p for interaction = 0.87 for fFN and 0.18 for CL).Conclusion: Maintenance tocolytic therapy with nifedipine is ineffective and not dependent on fFN or CL status.
KW - Cervical length
KW - fetal fibronectin
KW - maintenance tocolysis
UR - http://www.scopus.com/inward/record.url?scp=84958206681&partnerID=8YFLogxK
U2 - 10.3109/14767058.2015.1053863
DO - 10.3109/14767058.2015.1053863
M3 - Article
C2 - 26103778
AN - SCOPUS:84958206681
SN - 1476-7058
VL - 29
SP - 1556
EP - 1561
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 10
ER -