Abstract
Objectives
To evaluate ultrasonographically fetal growth trajectories, placental biometry and umbilical artery (UA) Dopplers in growth-restricted pregnancies of overnourished adolescent ewes and normally-developing pregnancies of control-fed ewes.
Study Design
Singleton pregnancies were established using embryo transfer in 42 adolescent ewes, which were overnourished (n=27) or control-fed (n=15), scanned at weekly intervals from 83–126d and necropsied at 131d gestation (term=145d).
Results
Ultrasonographic placental measurements were reduced and UA Doppler indices increased from 83d, whilst measurements of fetal abdominal circumference and femur length, renal volume and tibia length, and biparietal diameter were reduced from 98d, 105d and 112d, respectively, in overnourished versus control-intake pregnancies.
Conclusions
Overnourishment of adolescent sheep dams produced late-onset asymmetrical fetal growth restriction, commensurate with brain sparing. Ultrasonographic placental biometry was already reduced and UA Doppler indices increased by mid-gestation in overnourished pregnancies, preceding reduced fetal growth velocity and indicative of an early nutritionally-mediated insult on placental development.
To evaluate ultrasonographically fetal growth trajectories, placental biometry and umbilical artery (UA) Dopplers in growth-restricted pregnancies of overnourished adolescent ewes and normally-developing pregnancies of control-fed ewes.
Study Design
Singleton pregnancies were established using embryo transfer in 42 adolescent ewes, which were overnourished (n=27) or control-fed (n=15), scanned at weekly intervals from 83–126d and necropsied at 131d gestation (term=145d).
Results
Ultrasonographic placental measurements were reduced and UA Doppler indices increased from 83d, whilst measurements of fetal abdominal circumference and femur length, renal volume and tibia length, and biparietal diameter were reduced from 98d, 105d and 112d, respectively, in overnourished versus control-intake pregnancies.
Conclusions
Overnourishment of adolescent sheep dams produced late-onset asymmetrical fetal growth restriction, commensurate with brain sparing. Ultrasonographic placental biometry was already reduced and UA Doppler indices increased by mid-gestation in overnourished pregnancies, preceding reduced fetal growth velocity and indicative of an early nutritionally-mediated insult on placental development.
Original language | English |
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Pages (from-to) | 1410.e6-141.e15 |
Number of pages | 10 |
Journal | American Journal of Obstetrics and Gynecology |
Volume | 207 |
Issue number | 2 |
Early online date | 14 May 2012 |
DOIs | |
Publication status | Published - Aug 2012 |
Keywords
- fetal growth restriction
- placental biometry
- umbilical artery Doppler
- adolescent sheep
- ultrasound