Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation

Dale A. Redmer, Justin S. Luther, John Milne, Raymond Aitken, Mary Lynn Johnson, Pawel P. Borowicz, Magda A. Borowicz, Lawrence P. Reynolds, Jacqueline Wallace

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To establish the basis for altered placental development and function previously observed at late gestation, fetoplacental growth and placental vascular development were measured at three stages of gestation in a nutritional paradigm of compromised pregnancy. Singleton pregnancies to a single sire were established and thereafter adolescent ewes were offered an optimal control (C) or a high (H) dietary intake. At day 50, the H group had elevated maternal insulin and amniotic glucose, whereas mass of the fetus and placenta were unaltered. At day 90, the H group exhibited elevated maternal insulin, IGF1 and glucose; fetal weight and glucose concentrations in H were increased relative to C, but placental weight was independent of nutrition. By day 130, total placentome weight in the H group was reduced by 46% and was associated with lower fetal glucose and a 20% reduction in fetal weight. As pregnancy progressed from day 50 to 130, the parameters of vascular development in the maternal and fetal components of the placenta increased. in the fetal cotyledon, high dietary intakes were associated with impaired vascular development at day 50 and an increase in capillary number at day 90. At day 130, all vascular indices were independent of nutrition. Thus, high dietary intakes to promote rapid maternal growth influence capillary development in the fetal portion of the placenta during early to mid-pregnancy and may underlie the subsequent reduction in placental mass and hence fetal nutrient supply observed during the final third of gestation.

Original languageEnglish
Pages (from-to)749-757
Number of pages9
JournalReproduction
Volume137
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • UTERINE BLOOD-FLOW
  • GROWING ADOLESCENT
  • PLACENTAL GROWTH
  • PROGESTERONE CONCENTRATIONS
  • CELL-PROLIFERATION
  • RESTRICTED FETUSES
  • ANGIOGENIC FACTORS
  • FACTOR EXPRESSION
  • ENDOCRINE STATUS
  • MATERNAL GROWTH

Cite this

Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation. / Redmer, Dale A.; Luther, Justin S.; Milne, John; Aitken, Raymond; Johnson, Mary Lynn; Borowicz, Pawel P.; Borowicz, Magda A.; Reynolds, Lawrence P.; Wallace, Jacqueline.

In: Reproduction, Vol. 137, No. 4, 04.2009, p. 749-757.

Research output: Contribution to journalArticle

Redmer, DA, Luther, JS, Milne, J, Aitken, R, Johnson, ML, Borowicz, PP, Borowicz, MA, Reynolds, LP & Wallace, J 2009, 'Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation', Reproduction, vol. 137, no. 4, pp. 749-757. https://doi.org/10.1530/REP-08-0516
Redmer, Dale A. ; Luther, Justin S. ; Milne, John ; Aitken, Raymond ; Johnson, Mary Lynn ; Borowicz, Pawel P. ; Borowicz, Magda A. ; Reynolds, Lawrence P. ; Wallace, Jacqueline. / Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation. In: Reproduction. 2009 ; Vol. 137, No. 4. pp. 749-757.
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AU - Milne, John

AU - Aitken, Raymond

AU - Johnson, Mary Lynn

AU - Borowicz, Pawel P.

AU - Borowicz, Magda A.

AU - Reynolds, Lawrence P.

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N2 - To establish the basis for altered placental development and function previously observed at late gestation, fetoplacental growth and placental vascular development were measured at three stages of gestation in a nutritional paradigm of compromised pregnancy. Singleton pregnancies to a single sire were established and thereafter adolescent ewes were offered an optimal control (C) or a high (H) dietary intake. At day 50, the H group had elevated maternal insulin and amniotic glucose, whereas mass of the fetus and placenta were unaltered. At day 90, the H group exhibited elevated maternal insulin, IGF1 and glucose; fetal weight and glucose concentrations in H were increased relative to C, but placental weight was independent of nutrition. By day 130, total placentome weight in the H group was reduced by 46% and was associated with lower fetal glucose and a 20% reduction in fetal weight. As pregnancy progressed from day 50 to 130, the parameters of vascular development in the maternal and fetal components of the placenta increased. in the fetal cotyledon, high dietary intakes were associated with impaired vascular development at day 50 and an increase in capillary number at day 90. At day 130, all vascular indices were independent of nutrition. Thus, high dietary intakes to promote rapid maternal growth influence capillary development in the fetal portion of the placenta during early to mid-pregnancy and may underlie the subsequent reduction in placental mass and hence fetal nutrient supply observed during the final third of gestation.

AB - To establish the basis for altered placental development and function previously observed at late gestation, fetoplacental growth and placental vascular development were measured at three stages of gestation in a nutritional paradigm of compromised pregnancy. Singleton pregnancies to a single sire were established and thereafter adolescent ewes were offered an optimal control (C) or a high (H) dietary intake. At day 50, the H group had elevated maternal insulin and amniotic glucose, whereas mass of the fetus and placenta were unaltered. At day 90, the H group exhibited elevated maternal insulin, IGF1 and glucose; fetal weight and glucose concentrations in H were increased relative to C, but placental weight was independent of nutrition. By day 130, total placentome weight in the H group was reduced by 46% and was associated with lower fetal glucose and a 20% reduction in fetal weight. As pregnancy progressed from day 50 to 130, the parameters of vascular development in the maternal and fetal components of the placenta increased. in the fetal cotyledon, high dietary intakes were associated with impaired vascular development at day 50 and an increase in capillary number at day 90. At day 130, all vascular indices were independent of nutrition. Thus, high dietary intakes to promote rapid maternal growth influence capillary development in the fetal portion of the placenta during early to mid-pregnancy and may underlie the subsequent reduction in placental mass and hence fetal nutrient supply observed during the final third of gestation.

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KW - GROWING ADOLESCENT

KW - PLACENTAL GROWTH

KW - PROGESTERONE CONCENTRATIONS

KW - CELL-PROLIFERATION

KW - RESTRICTED FETUSES

KW - ANGIOGENIC FACTORS

KW - FACTOR EXPRESSION

KW - ENDOCRINE STATUS

KW - MATERNAL GROWTH

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DO - 10.1530/REP-08-0516

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JO - Reproduction

JF - Reproduction

SN - 1470-1626

IS - 4

ER -