Fibrinogen depleting agents reduce fibrinogen in blood plasma, reduce blood viscosity and hence increase blood flow. This may help remove the blood clot blocking the artery and re-establish blood flow to the affected area of the brain after an ischaemic stroke. The risk of haemorrhage may be less than with thrombolytic agents. This is an update of a Cochrane review first published in 1997 and last updated in 2003.
Hao, Z., Liu, M., Counsell, C., Wardlaw, J. M., Lin, S., & Zhao, X. (2012). Fibrinogen depleting agents for acute ischaemic stroke. Cochrane Database of Systematic Reviews, (3), [CD000091]. https://doi.org/10.1002/14651858.CD000091.pub2