Field-cycled PEDRI imaging of free radicals with detection at 450 mT

David John Lurie (Corresponding Author), Gareth Reynold Davies, M. A. Foster, James McDonald Strachan Hutchison

Research output: Contribution to journalArticle

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Abstract

This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality and sensitivity. The detection magnetic field is provided by a superconducting magnet, giving high stability and homogeneity. Field cycling is implemented by switching on and off the current in an internal, coaxial, resistive secondary magnet that partially cancels the superconducting magnet's field at the sample; the secondary magnet is actively shielded to avoid eddy currents. EPR irradiation takes place at ∼5 mT, following which the field is switched to 450 mT in 40 ms for NMR signal detection. Full details of the imager's subsystems are given, and experiments to image the distribution of stable free radical contrast agents in phantoms and in anesthetized rats are described.

Original languageEnglish
Pages (from-to)175-181
Number of pages6
JournalMagnetic Resonance Imaging
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Magnets
Superconducting magnets
Magnetic Fields
Free radicals
Image sensors
Free Radicals
Magnetic fields
Imaging techniques
Signal detection
Eddy currents
Imaging systems
Image quality
Contrast Media
Paramagnetic resonance
Rats
Nuclear magnetic resonance
Irradiation
Experiments
Superconductivity

Keywords

  • PEDRI
  • field-cycling
  • Overhauser imaging
  • free radical

Cite this

Field-cycled PEDRI imaging of free radicals with detection at 450 mT. / Lurie, David John (Corresponding Author); Davies, Gareth Reynold; Foster, M. A.; Hutchison, James McDonald Strachan.

In: Magnetic Resonance Imaging, Vol. 23, No. 2, 02.2005, p. 175-181.

Research output: Contribution to journalArticle

Lurie, David John ; Davies, Gareth Reynold ; Foster, M. A. ; Hutchison, James McDonald Strachan. / Field-cycled PEDRI imaging of free radicals with detection at 450 mT. In: Magnetic Resonance Imaging. 2005 ; Vol. 23, No. 2. pp. 175-181.
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