Fish immune responses to experimental and natural infection with helminth parasites

C. J. Secombes*, L. H. Chappell

*Corresponding author for this work

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Selected features of the responses by fish to helminth parasites are discussed and comparison is made where appropriate with mammals. These include: (i) Factors influencing host specificity and consideration of the mechanisms that underpin the restriction of some parasites in their host spectrum, (ii) How fish leucocytes kill helminth larvae, with emphasis on the role of released oxygen (ROS) and nitrogen (RNS) free radicals from macrophages, (iii) Immune evasion strategies used by fish helminths, including invasion of immunologically privileged sites, encystment, adsorption of host proteins on the parasite surface, and high surface membrane turnover, (iv) Potential immunogens for vaccination and use for immonodiagnosis of infection, and (v) Natural and induced protection against helminths, with emphasis on the potential for future vaccination strategies.

Original languageEnglish
Pages (from-to)167-177
Number of pages11
JournalAnnual Review of Fish Diseases
Volume6
DOIs
Publication statusPublished - 1996

Fingerprint

Helminths
Fishes
Parasites
Infection
Vaccination
Immune Evasion
Host Specificity
Adsorption
Free Radicals
Larva
Mammals
Leukocytes
Nitrogen
Macrophages
Oxygen
Membranes
Proteins

Keywords

  • Fish
  • Helminth
  • Immunity
  • Vaccination

ASJC Scopus subject areas

  • Immunology

Cite this

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AB - Selected features of the responses by fish to helminth parasites are discussed and comparison is made where appropriate with mammals. These include: (i) Factors influencing host specificity and consideration of the mechanisms that underpin the restriction of some parasites in their host spectrum, (ii) How fish leucocytes kill helminth larvae, with emphasis on the role of released oxygen (ROS) and nitrogen (RNS) free radicals from macrophages, (iii) Immune evasion strategies used by fish helminths, including invasion of immunologically privileged sites, encystment, adsorption of host proteins on the parasite surface, and high surface membrane turnover, (iv) Potential immunogens for vaccination and use for immonodiagnosis of infection, and (v) Natural and induced protection against helminths, with emphasis on the potential for future vaccination strategies.

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