A composition comprising a translocation sequence derived from a fish pathogen and a heterologous payload coupled to the translocation sequence is provided. The composition is able to translocate across the plasma membrane of a eukaryotic cell, for example a fish cell, and thus stimulate an immune response. Accordingly, nucleic acids, vectors, host cells, compositions and vaccines based thereon are also provided.
Original languageEnglish
Patent numberWO2014191759
IPCA61K38/16; C07K14/37; C12N15/62
Priority date30/05/13
Publication statusPublished - 4 Dec 2014

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    Wawra, S., Van West, P., & Secombes, C. J. (2014). IPC No. A61K38/16; C07K14/37; C12N15/62. Fish Vaccine. (Patent No. WO2014191759).