FK-506 - AN IMMUNOSUPPRESSANT FOR THE 1990S

A M MACLEOD, A W THOMSON

Research output: Contribution to journalLiterature review

49 Citations (Scopus)

Abstract

The novel macrolide immunosuppressant FK 506 is a powerful and selective anti-T-cell agent which has a similar mode of action to that of cyclosporin. Clinical studies of FK 506 in liver allograft recipients indicate a lower risk/benefit ratio than with cyclosporin, and wider evaluation of FK 506 in transplant recipients is now under way in multicentre, prospective, controlled trials in both Europe and North America.

Original languageEnglish
Pages (from-to)25-27
Number of pages3
JournalThe Lancet
Volume337
Issue number8732
Publication statusPublished - 5 Jan 1991

Keywords

  • PEPTIDYL-PROLYL ISOMERASE
  • RECEIVING FK-506
  • DRUG FK-506
  • FK506
  • TRANSPLANTATION
  • RATS
  • CYCLOSPORINE
  • COMBINATION
  • ACTIVATION
  • INHIBITION

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