Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns

Win Zaw, D. C. Knoppert, Silva,O. da

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.

    Original languageEnglish
    Pages (from-to)642-646
    Number of pages4
    JournalPharmacotherapy
    Volume21
    Issue number5
    DOIs
    Publication statusPublished - 2001

    Keywords

    • CONSCIOUS SEDATION
    • POPULATION PHARMACOKINETICS
    • INTRAVENOUS MIDAZOLAM
    • PREMATURE-INFANT
    • LORAZEPAM
    • CHILDREN
    • FENTANYL
    • NEONATE

    Cite this

    Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns. / Zaw, Win; Knoppert, D. C.; da, Silva,O.

    In: Pharmacotherapy, Vol. 21, No. 5, 2001, p. 642-646.

    Research output: Contribution to journalArticle

    Zaw, Win ; Knoppert, D. C. ; da, Silva,O. / Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns. In: Pharmacotherapy. 2001 ; Vol. 21, No. 5. pp. 642-646.
    @article{4c0308d475b24075a6fd95a27e57f96e,
    title = "Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns",
    abstract = "Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.",
    keywords = "CONSCIOUS SEDATION, POPULATION PHARMACOKINETICS, INTRAVENOUS MIDAZOLAM, PREMATURE-INFANT, LORAZEPAM, CHILDREN, FENTANYL, NEONATE",
    author = "Win Zaw and Knoppert, {D. C.} and Silva,O. da",
    year = "2001",
    doi = "10.1592/phco.21.6.642.34545",
    language = "English",
    volume = "21",
    pages = "642--646",
    journal = "Pharmacotherapy",
    issn = "0277-0008",
    publisher = "Pharmacotherapy Publications Inc.",
    number = "5",

    }

    TY - JOUR

    T1 - Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns

    AU - Zaw, Win

    AU - Knoppert, D. C.

    AU - da, Silva,O.

    PY - 2001

    Y1 - 2001

    N2 - Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.

    AB - Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.

    KW - CONSCIOUS SEDATION

    KW - POPULATION PHARMACOKINETICS

    KW - INTRAVENOUS MIDAZOLAM

    KW - PREMATURE-INFANT

    KW - LORAZEPAM

    KW - CHILDREN

    KW - FENTANYL

    KW - NEONATE

    U2 - 10.1592/phco.21.6.642.34545

    DO - 10.1592/phco.21.6.642.34545

    M3 - Article

    VL - 21

    SP - 642

    EP - 646

    JO - Pharmacotherapy

    JF - Pharmacotherapy

    SN - 0277-0008

    IS - 5

    ER -