Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns

Win Zaw, D. C. Knoppert, Silva,O. da

    Research output: Contribution to journalArticle

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    Abstract

    Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.

    Original languageEnglish
    Pages (from-to)642-646
    Number of pages4
    JournalPharmacotherapy
    Volume21
    Issue number5
    DOIs
    Publication statusPublished - 2001

    Keywords

    • CONSCIOUS SEDATION
    • POPULATION PHARMACOKINETICS
    • INTRAVENOUS MIDAZOLAM
    • PREMATURE-INFANT
    • LORAZEPAM
    • CHILDREN
    • FENTANYL
    • NEONATE

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