Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya

Hai Deng, David O’Hagan (Corresponding Author), Christoph Schaffrath

Research output: Contribution to journalArticle

Abstract

This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C–F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to organic fluorine is novel and of contemporary interest.

Original languageEnglish
Pages (from-to)773-784
Number of pages12
JournalNatural Product Reports
Volume21
Issue number6
DOIs
Publication statusPublished - 2004

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Fluorine
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Biosynthesis
Biochemistry
Streptomyces
Biotransformation
Purification
Bacteria
Enzymes
fluorinase

Cite this

Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya. / Deng, Hai; O’Hagan, David (Corresponding Author); Schaffrath, Christoph .

In: Natural Product Reports, Vol. 21, No. 6, 2004, p. 773-784.

Research output: Contribution to journalArticle

Deng, Hai ; O’Hagan, David ; Schaffrath, Christoph . / Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya. In: Natural Product Reports. 2004 ; Vol. 21, No. 6. pp. 773-784.
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