Folic acid deficiency and cancer

Susan Joyce Duthie

    Research output: Contribution to journalArticle

    324 Citations (Scopus)

    Abstract

    Folic acid deficiency in humans has been linked with megaloblastic anaemia, neural tube defects in the neonate, and heart disease. Folate has also been implicated in the development of cancer, especially cancer of the colorectum. There appear to be two principal mechanisms through which low folate status may increase the risk of malignancy. Folate deficiency, by reducing intracellular S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to inappropriate activation of proto-oncogenes and induction of malignant transformation. Alternatively, folic acid is crucial for normal DNA synthesis and repair. Folate deficiency may cause an imbalance in DNA precursors, uracil misincorporation into DNA, and chromosome breakage. This chapter briefly describes the epidemiological data supporting the involvement of folic acid in the aetiology of cancer. It also assesses the evidence from cellular, animal and human studies that folic acid can modulate DNA by such mechanisms.

    Original languageEnglish
    Pages (from-to)578-592
    Number of pages15
    JournalBritish Medical Bulletin
    Volume55
    Issue number3
    Publication statusPublished - 1999

    Keywords

    • HAMSTER OVARY CELLS
    • DEOXYNUCLEOTIDE POOL IMBALANCE
    • INVASIVE CERVICAL-CANCER
    • FOLATE-DEFICIENCY
    • URACIL MISINCORPORATION
    • COLON-CANCER
    • PLASMA HOMOCYSTEINE
    • SQUAMOUS METAPLASIA
    • ULCERATIVE-COLITIS
    • COLORECTAL-CANCER

    Cite this

    Duthie, S. J. (1999). Folic acid deficiency and cancer. British Medical Bulletin, 55(3), 578-592.