Folic acid use in pregnancy and embryo selection

P Haggarty, DM Campbell, S Duthie, K Andrews, G Hoad, C. Piyathilake, I Fraser, G McNeill

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective Folic acid supplement use is recommended in pregnancy to reduce the risk of neural tube defect but concerns have been raised that increasing folic acid intake may select for embryos with genotypes that increase disease risk in the offspring. Our aim was to test for this effect.
Design Observational prospective cohort study.
Setting Aberdeen Maternity Hospital.
Population or Sample Women born before the introduction of folic acid advice (1970-80) and carrying singleton pregnancies (n = 1234) and their offspring (n = 1083) born after (2001-03).
Methods We measured the genotype (MTHFR C677T and A1298C, MTR A2756G, MTRR A66G and TCN G776C) of mothers and their offspring, maternal supplement intake, intake of folate and vitamin B12 from natural foods and maternal blood folate and B12 status at 19 weeks of gestation.
Main outcome measures B vitamin related genotype of the offspring.
Results There were no significant differences in any of the five genotype frequencies between mothers and their babies. There was no deviation from Hardy-Weinberg equilibrium in either generation and no change in the frequency of doubly homozygous MTHFR variants (677 TT/1298 CC). The genotype of the offspring was not related to maternal periconceptual supplement use, folate intake from foods or plasma and red cell folate measured at 19 weeks of gestation.
Conclusions We found no evidence to support the concern that folic acid fortification or supplement use in pregnancy results in selection of deleterious genotypes.

Original languageEnglish
Pages (from-to)851-856
Number of pages6
JournalBJOG-An International Journal of Obstetrics and Gynaecology
Volume115
Issue number7
DOIs
Publication statusPublished - Jun 2008

Keywords

  • embryo
  • fertility
  • folic acid
  • MTHFR
  • selection
  • genetic selection
  • folate
  • polymorphisms
  • homocysteine
  • metaanalysis
  • risk
  • fortification
  • frequency
  • defects
  • vitamin

Cite this

Folic acid use in pregnancy and embryo selection. / Haggarty, P; Campbell, DM; Duthie, S; Andrews, K; Hoad, G; Piyathilake, C.; Fraser, I; McNeill, G.

In: BJOG-An International Journal of Obstetrics and Gynaecology, Vol. 115, No. 7, 06.2008, p. 851-856.

Research output: Contribution to journalArticle

Haggarty, P ; Campbell, DM ; Duthie, S ; Andrews, K ; Hoad, G ; Piyathilake, C. ; Fraser, I ; McNeill, G. / Folic acid use in pregnancy and embryo selection. In: BJOG-An International Journal of Obstetrics and Gynaecology. 2008 ; Vol. 115, No. 7. pp. 851-856.
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abstract = "Objective Folic acid supplement use is recommended in pregnancy to reduce the risk of neural tube defect but concerns have been raised that increasing folic acid intake may select for embryos with genotypes that increase disease risk in the offspring. Our aim was to test for this effect. Design Observational prospective cohort study. Setting Aberdeen Maternity Hospital. Population or Sample Women born before the introduction of folic acid advice (1970-80) and carrying singleton pregnancies (n = 1234) and their offspring (n = 1083) born after (2001-03). Methods We measured the genotype (MTHFR C677T and A1298C, MTR A2756G, MTRR A66G and TCN G776C) of mothers and their offspring, maternal supplement intake, intake of folate and vitamin B12 from natural foods and maternal blood folate and B12 status at 19 weeks of gestation. Main outcome measures B vitamin related genotype of the offspring. Results There were no significant differences in any of the five genotype frequencies between mothers and their babies. There was no deviation from Hardy-Weinberg equilibrium in either generation and no change in the frequency of doubly homozygous MTHFR variants (677 TT/1298 CC). The genotype of the offspring was not related to maternal periconceptual supplement use, folate intake from foods or plasma and red cell folate measured at 19 weeks of gestation. Conclusions We found no evidence to support the concern that folic acid fortification or supplement use in pregnancy results in selection of deleterious genotypes.",
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AU - Fraser, I

AU - McNeill, G

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N2 - Objective Folic acid supplement use is recommended in pregnancy to reduce the risk of neural tube defect but concerns have been raised that increasing folic acid intake may select for embryos with genotypes that increase disease risk in the offspring. Our aim was to test for this effect. Design Observational prospective cohort study. Setting Aberdeen Maternity Hospital. Population or Sample Women born before the introduction of folic acid advice (1970-80) and carrying singleton pregnancies (n = 1234) and their offspring (n = 1083) born after (2001-03). Methods We measured the genotype (MTHFR C677T and A1298C, MTR A2756G, MTRR A66G and TCN G776C) of mothers and their offspring, maternal supplement intake, intake of folate and vitamin B12 from natural foods and maternal blood folate and B12 status at 19 weeks of gestation. Main outcome measures B vitamin related genotype of the offspring. Results There were no significant differences in any of the five genotype frequencies between mothers and their babies. There was no deviation from Hardy-Weinberg equilibrium in either generation and no change in the frequency of doubly homozygous MTHFR variants (677 TT/1298 CC). The genotype of the offspring was not related to maternal periconceptual supplement use, folate intake from foods or plasma and red cell folate measured at 19 weeks of gestation. Conclusions We found no evidence to support the concern that folic acid fortification or supplement use in pregnancy results in selection of deleterious genotypes.

AB - Objective Folic acid supplement use is recommended in pregnancy to reduce the risk of neural tube defect but concerns have been raised that increasing folic acid intake may select for embryos with genotypes that increase disease risk in the offspring. Our aim was to test for this effect. Design Observational prospective cohort study. Setting Aberdeen Maternity Hospital. Population or Sample Women born before the introduction of folic acid advice (1970-80) and carrying singleton pregnancies (n = 1234) and their offspring (n = 1083) born after (2001-03). Methods We measured the genotype (MTHFR C677T and A1298C, MTR A2756G, MTRR A66G and TCN G776C) of mothers and their offspring, maternal supplement intake, intake of folate and vitamin B12 from natural foods and maternal blood folate and B12 status at 19 weeks of gestation. Main outcome measures B vitamin related genotype of the offspring. Results There were no significant differences in any of the five genotype frequencies between mothers and their babies. There was no deviation from Hardy-Weinberg equilibrium in either generation and no change in the frequency of doubly homozygous MTHFR variants (677 TT/1298 CC). The genotype of the offspring was not related to maternal periconceptual supplement use, folate intake from foods or plasma and red cell folate measured at 19 weeks of gestation. Conclusions We found no evidence to support the concern that folic acid fortification or supplement use in pregnancy results in selection of deleterious genotypes.

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KW - polymorphisms

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KW - frequency

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