Foodomics study of micronutrients: the case of folates

Susan J Duthie

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    This chapter explores how various foodomics technologies based on liquid chromatography--mass spectrometry?mass spectrometry (LC--MS?MS) are used to examine mechanistically the links between folate status and human health. The importance (and difficulties) of accurately measuring blood folates using LC--MS?MS in human population monitoring is discussed. The application of proteomics to investigate the effect of folate status on global protein expression and metabolic pathways associated with immune function, genomic stability, and malignant transformation is described in detail using examples from cell and animal models and from a human intervention study. Finally, the use of LC--MS?MS to investigate the impact of folate status on abnormal DNA methylation as a common mechanism linking altered gene expression and cell proliferation in both colon cancer and CVD is discussed.
    Original languageEnglish
    Title of host publicationFoodomics
    Subtitle of host publicationadvanced mass spectrometry in modern food science and nutrition
    EditorsA Cifuentes
    PublisherWiley
    Pages381-403
    Number of pages23
    ISBN (Print)978-1-1181-6945-2, 111816945X
    DOIs
    Publication statusPublished - 26 Apr 2013

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    Duthie, S. J. (2013). Foodomics study of micronutrients: the case of folates. In A. Cifuentes (Ed.), Foodomics: advanced mass spectrometry in modern food science and nutrition (pp. 381-403). Wiley. https://doi.org/10.1002/9781118537282.ch13