Foodomics study of micronutrients

the case of folates

Susan J Duthie

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    This chapter explores how various foodomics technologies based on liquid chromatography--mass spectrometry?mass spectrometry (LC--MS?MS) are used to examine mechanistically the links between folate status and human health. The importance (and difficulties) of accurately measuring blood folates using LC--MS?MS in human population monitoring is discussed. The application of proteomics to investigate the effect of folate status on global protein expression and metabolic pathways associated with immune function, genomic stability, and malignant transformation is described in detail using examples from cell and animal models and from a human intervention study. Finally, the use of LC--MS?MS to investigate the impact of folate status on abnormal DNA methylation as a common mechanism linking altered gene expression and cell proliferation in both colon cancer and CVD is discussed.
    Original languageEnglish
    Title of host publicationFoodomics
    Subtitle of host publicationadvanced mass spectrometry in modern food science and nutrition
    EditorsA Cifuentes
    PublisherWiley
    Pages381-403
    Number of pages23
    ISBN (Print)978-1-1181-6945-2, 111816945X
    DOIs
    Publication statusPublished - 26 Apr 2013

    Fingerprint

    Micronutrients
    Folic Acid
    Mass Spectrometry
    Genomic Instability
    DNA Methylation
    Metabolic Networks and Pathways
    Liquid Chromatography
    Proteomics
    Colonic Neoplasms
    Health Status
    Animal Models
    Cell Proliferation
    Technology
    Gene Expression
    Population
    Proteins

    Cite this

    Duthie, S. J. (2013). Foodomics study of micronutrients: the case of folates. In A. Cifuentes (Ed.), Foodomics: advanced mass spectrometry in modern food science and nutrition (pp. 381-403). Wiley. https://doi.org/10.1002/9781118537282.ch13

    Foodomics study of micronutrients : the case of folates. / Duthie, Susan J.

    Foodomics: advanced mass spectrometry in modern food science and nutrition. ed. / A Cifuentes. Wiley, 2013. p. 381-403.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Duthie, SJ 2013, Foodomics study of micronutrients: the case of folates. in A Cifuentes (ed.), Foodomics: advanced mass spectrometry in modern food science and nutrition. Wiley, pp. 381-403. https://doi.org/10.1002/9781118537282.ch13
    Duthie SJ. Foodomics study of micronutrients: the case of folates. In Cifuentes A, editor, Foodomics: advanced mass spectrometry in modern food science and nutrition. Wiley. 2013. p. 381-403 https://doi.org/10.1002/9781118537282.ch13
    Duthie, Susan J. / Foodomics study of micronutrients : the case of folates. Foodomics: advanced mass spectrometry in modern food science and nutrition. editor / A Cifuentes. Wiley, 2013. pp. 381-403
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