Formation of propionate and butyrate by the human colonic microbiota

Research output: Contribution to journalLiterature review

151 Citations (Scopus)
7 Downloads (Pure)

Abstract

The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here we provide an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. A detailed understanding of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimize SCFA supply to the host. This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)29-41
Number of pages13
JournalEnvironmental Microbiology
Volume19
Issue number1
Early online date5 Nov 2016
DOIs
Publication statusPublished - Jan 2017

Fingerprint

Volatile Fatty Acids
Butyrates
Microbiota
Propionates
short chain fatty acids
butyrates
propionates
fatty acid
intestinal microorganisms
carbohydrate
metabolite
digestive system
metabolites
Dietary Carbohydrates
Bacteria
propanediols
ecophysiology
Propylene Glycol
health promotion
bacterium

Cite this

Formation of propionate and butyrate by the human colonic microbiota. / Louis, Petra; Flint, Harry J.

In: Environmental Microbiology, Vol. 19, No. 1, 01.2017, p. 29-41.

Research output: Contribution to journalLiterature review

@article{58690af1a07a4f1ab945ac45d8edb13c,
title = "Formation of propionate and butyrate by the human colonic microbiota",
abstract = "The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here we provide an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. A detailed understanding of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimize SCFA supply to the host. This article is protected by copyright. All rights reserved.",
author = "Petra Louis and Flint, {Harry J.}",
note = "Acknowledgements The authors receive financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). We would like to thank Sylvia Duncan for SCFA data of F. prausnitzii grown under different pH regimes and for critically reading the manuscript. The authors declare that they have no conflicts of interest.",
year = "2017",
month = "1",
doi = "10.1111/1462-2920.13589",
language = "English",
volume = "19",
pages = "29--41",
journal = "Environmental Microbiology",
issn = "1462-2912",
publisher = "BLACKWELL PUBLISHING LTD",
number = "1",

}

TY - JOUR

T1 - Formation of propionate and butyrate by the human colonic microbiota

AU - Louis, Petra

AU - Flint, Harry J.

N1 - Acknowledgements The authors receive financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). We would like to thank Sylvia Duncan for SCFA data of F. prausnitzii grown under different pH regimes and for critically reading the manuscript. The authors declare that they have no conflicts of interest.

PY - 2017/1

Y1 - 2017/1

N2 - The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here we provide an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. A detailed understanding of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimize SCFA supply to the host. This article is protected by copyright. All rights reserved.

AB - The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here we provide an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. A detailed understanding of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimize SCFA supply to the host. This article is protected by copyright. All rights reserved.

U2 - 10.1111/1462-2920.13589

DO - 10.1111/1462-2920.13589

M3 - Literature review

VL - 19

SP - 29

EP - 41

JO - Environmental Microbiology

JF - Environmental Microbiology

SN - 1462-2912

IS - 1

ER -