Fractal dimension analysis of MR images reveals grey matter structure irregularities in schizophrenia.

Anca-Larisa Sandu-Giuraniuc; Inge-Andre Rasmussen Jr.; Arvid  Lundervold; Frank Kreuder; Gesche Neckelmann; Kenneth Hugdahl; Karsten Specht

doi:10.1016/j.compmedimag.2007.10.005

Fractal dimension analysis of MR images reveals grey matter structure irregularities in schizophrenia.

Anca-Larisa Sandu-Giuraniuc^* (Corresponding Author), Inge-Andre Rasmussen Jr., Arvid Lundervold, Frank Kreuder, Gesche Neckelmann, Kenneth Hugdahl, Karsten Specht

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

The fractal dimension (FD) was used to reveal brain structure irregularities in patients with schizophrenia. FD provides a unique way of quantifying the shape complexity of cortical folding of the human brain. MR images were obtained from seven patients with schizophrenia that were compared with six healthy control subjects. The MR images were first segmented, and the FD was calculated for the grey/white matter boundary for the whole brain and the hemispheres separately, using the box-counting and Minkowski-Bouligand methods. The results showed that the patients had larger FD values than the controls, for the whole brain volume and right hemisphere.

Original language	English
Pages (from-to)	150-158
Number of pages	9
Journal	Computerized Medical Imaging and Graphics
Volume	32
Issue number	2
Early online date	18 Dec 2007
DOIs	https://doi.org/10.1016/j.compmedimag.2007.10.005
Publication status	Published - 31 Mar 2008
Externally published	Yes

Bibliographical note

The present research was financially supported by a grant to Kenneth Hugdahl from the Alfried Krupp von Bohlen und Halbach Stiftung, Germany.

The software and the data sets can be made available to other researchers after inquiry to the principal investigator, Kenneth Hugdahl.

Keywords

Fractal dimension
Brain imaging
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Fractal dimension analysis of MR images reveals grey matter structure irregularities in schizophrenia.",

abstract = "The fractal dimension (FD) was used to reveal brain structure irregularities in patients with schizophrenia. FD provides a unique way of quantifying the shape complexity of cortical folding of the human brain. MR images were obtained from seven patients with schizophrenia that were compared with six healthy control subjects. The MR images were first segmented, and the FD was calculated for the grey/white matter boundary for the whole brain and the hemispheres separately, using the box-counting and Minkowski-Bouligand methods. The results showed that the patients had larger FD values than the controls, for the whole brain volume and right hemisphere.",

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note = "The present research was financially supported by a grant to Kenneth Hugdahl from the Alfried Krupp von Bohlen und Halbach Stiftung, Germany. The software and the data sets can be made available to other researchers after inquiry to the principal investigator, Kenneth Hugdahl.",

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AU - Sandu-Giuraniuc, Anca-Larisa

AU - Rasmussen Jr., Inge-Andre

AU - Lundervold, Arvid

AU - Kreuder, Frank

AU - Neckelmann, Gesche

AU - Hugdahl, Kenneth

AU - Specht, Karsten

N1 - The present research was financially supported by a grant to Kenneth Hugdahl from the Alfried Krupp von Bohlen und Halbach Stiftung, Germany. The software and the data sets can be made available to other researchers after inquiry to the principal investigator, Kenneth Hugdahl.

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N2 - The fractal dimension (FD) was used to reveal brain structure irregularities in patients with schizophrenia. FD provides a unique way of quantifying the shape complexity of cortical folding of the human brain. MR images were obtained from seven patients with schizophrenia that were compared with six healthy control subjects. The MR images were first segmented, and the FD was calculated for the grey/white matter boundary for the whole brain and the hemispheres separately, using the box-counting and Minkowski-Bouligand methods. The results showed that the patients had larger FD values than the controls, for the whole brain volume and right hemisphere.

AB - The fractal dimension (FD) was used to reveal brain structure irregularities in patients with schizophrenia. FD provides a unique way of quantifying the shape complexity of cortical folding of the human brain. MR images were obtained from seven patients with schizophrenia that were compared with six healthy control subjects. The MR images were first segmented, and the FD was calculated for the grey/white matter boundary for the whole brain and the hemispheres separately, using the box-counting and Minkowski-Bouligand methods. The results showed that the patients had larger FD values than the controls, for the whole brain volume and right hemisphere.

KW - Fractal dimension

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DO - 10.1016/j.compmedimag.2007.10.005

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Fractal dimension analysis of MR images reveals grey matter structure irregularities in schizophrenia.

Abstract

Bibliographical note

Keywords

UN SDGs

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