Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas, Stephan Gadola, Ute Meier, Neil Thomas Young, Gillian Harcourt, Anastasios Karadimitris, Nikki Coumi, Dave Brown, Geoff Dusheiko, Vincenzo Cerundolo, Paul Klenerman

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
Original languageEnglish
Pages (from-to)2251-2257
Number of pages7
JournalJournal of Virology
Volume77
Issue number3
DOIs
Publication statusPublished - 1 Feb 2003

Keywords

  • Antigens, CD
  • Antigens, CD3
  • Antigens, CD56
  • Antigens, Differentiation, T-Lymphocyte
  • Hepatitis C
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocyte Subsets

Fingerprint Dive into the research topics of 'Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection'. Together they form a unique fingerprint.

  • Cite this

    Lucas, M., Gadola, S., Meier, U., Young, N. T., Harcourt, G., Karadimitris, A., Coumi, N., Brown, D., Dusheiko, G., Cerundolo, V., & Klenerman, P. (2003). Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection. Journal of Virology, 77(3), 2251-2257. https://doi.org/10.1128/JVI.77.3.2251-2257.2003