Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas, Stephan Gadola, Ute Meier, Neil Thomas Young, Gillian Harcourt, Anastasios Karadimitris, Nikki Coumi, Dave Brown, Geoff Dusheiko, Vincenzo Cerundolo, Paul Klenerman

Research output: Contribution to journalArticle

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Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
Original languageEnglish
Pages (from-to)2251-2257
Number of pages7
JournalJournal of Virology
Volume77
Issue number3
DOIs
Publication statusPublished - 1 Feb 2003

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Natural Killer T-Cells
Hepatitis C virus
natural killer cells
Virus Diseases
Hepacivirus
T-lymphocytes
Phenotype
phenotype
infection
blood
Polymerase Chain Reaction
liver
Liver
Infection
Population

Keywords

  • Antigens, CD
  • Antigens, CD3
  • Antigens, CD56
  • Antigens, Differentiation, T-Lymphocyte
  • Hepatitis C
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocyte Subsets

Cite this

Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection. / Lucas, Michaela; Gadola, Stephan; Meier, Ute; Young, Neil Thomas; Harcourt, Gillian; Karadimitris, Anastasios; Coumi, Nikki; Brown, Dave; Dusheiko, Geoff; Cerundolo, Vincenzo; Klenerman, Paul.

In: Journal of Virology, Vol. 77, No. 3, 01.02.2003, p. 2251-2257.

Research output: Contribution to journalArticle

Lucas, M, Gadola, S, Meier, U, Young, NT, Harcourt, G, Karadimitris, A, Coumi, N, Brown, D, Dusheiko, G, Cerundolo, V & Klenerman, P 2003, 'Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection', Journal of Virology, vol. 77, no. 3, pp. 2251-2257. https://doi.org/10.1128/JVI.77.3.2251-2257.2003
Lucas, Michaela ; Gadola, Stephan ; Meier, Ute ; Young, Neil Thomas ; Harcourt, Gillian ; Karadimitris, Anastasios ; Coumi, Nikki ; Brown, Dave ; Dusheiko, Geoff ; Cerundolo, Vincenzo ; Klenerman, Paul. / Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection. In: Journal of Virology. 2003 ; Vol. 77, No. 3. pp. 2251-2257.
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