Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas, Stephan Gadola, Ute Meier, Neil Thomas Young, Gillian Harcourt, Anastasios Karadimitris, Nikki Coumi, Dave Brown, Geoff Dusheiko, Vincenzo Cerundolo, Paul Klenerman

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
Original languageEnglish
Pages (from-to)2251-2257
Number of pages7
JournalJournal of Virology
Volume77
Issue number3
DOIs
Publication statusPublished - 1 Feb 2003

Keywords

  • Antigens, CD
  • Antigens, CD3
  • Antigens, CD56
  • Antigens, Differentiation, T-Lymphocyte
  • Hepatitis C
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocyte Subsets

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