TY - CHAP
T1 - From commensal to pathogen
T2 - Candida albicans
AU - Whittington, Amy
AU - Gow, Neil A.R.
AU - Hube, Bernhard
N1 - Acknowledgements
NG and AW were supported by the Wellcome Trust (080088, 086827, 075470 & 097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338). BH is supported by the Federal Ministry of Education and Research (BMBF: ERA Net PathoGenoMics CandiCol 0315901B), the Center for Sepsis Control and Care (CSCC – BMBF 01EO1002), the Deutsche Forschungsgemeinschaft (DFG Hu 528/15, 16 and 17), the Jena School for Microbial Communication (JSMC), and the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS).
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The attributes that allow Candida albicans to be a successful human commensal overlap with its ability to cause opportunistic disease. The ways in which C. albicans successfully transitions from a commensal to a pathogen involve many aspects of its growth and interaction with the host, including the host recognition of and response to the various cell types that characterise this fungal species. We discuss the factors that are important for commensal growth, stress responses, the role of the cell wall in immune recognition, attachment to and interactions with epithelial cells, and interactions with immune cells as key aspects of the commensal-pathogenic life style of this fungus.
AB - The attributes that allow Candida albicans to be a successful human commensal overlap with its ability to cause opportunistic disease. The ways in which C. albicans successfully transitions from a commensal to a pathogen involve many aspects of its growth and interaction with the host, including the host recognition of and response to the various cell types that characterise this fungal species. We discuss the factors that are important for commensal growth, stress responses, the role of the cell wall in immune recognition, attachment to and interactions with epithelial cells, and interactions with immune cells as key aspects of the commensal-pathogenic life style of this fungus.
UR - http://www.scopus.com/inward/record.url?scp=84946022933&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-39432-4_1
DO - 10.1007/978-3-642-39432-4_1
M3 - Chapter
AN - SCOPUS:84946022933
SN - 9783642394317
VL - 12
T3 - The Mycota
SP - 3
EP - 18
BT - Human Fungal Pathogens
PB - Springer Berlin / Heidelberg
ER -
