Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany

M. J. Mueller; V. Baracos; A. Bosy-Westphal; A. G. Dulloo; J. Eckel; K. C. H. Fearon; K. D. Hall; A. Pietrobelli; T. I. A. Sorensen; J. Speakman; P. Trayhurn; M. Visser; S. B. Heymsfield

doi:10.1111/obr.12187

Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany

M. J. Mueller^*, V. Baracos, A. Bosy-Westphal, A. G. Dulloo, J. Eckel, K. C. H. Fearon, K. D. Hall, A. Pietrobelli, T. I. A. Sorensen, J. Speakman, P. Trayhurn, M. Visser, S. B. Heymsfield

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss, there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus an understanding of body weight regulation involves an examination of the relationships between organs and tissues rather than individual organ and tissue masses only. The between organ/tissue mass relationships are associated with and explained by crosstalks between organs and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism.

Original language	English
Pages (from-to)	640-656
Number of pages	17
Journal	Obesity Reviews
Volume	15
Issue number	8
Early online date	17 Jul 2014
DOIs	https://doi.org/10.1111/obr.12187
Publication status	Published - Aug 2014

Bibliographical note

The authors wish to thank IASO for giving them the opportunity to organize the 2013 Stock Conference. Special thanks to David York and Natasha Joyner from IASO for their help in preparing and conducting the conference. The financial support provided by the following is acknowledged: BMBF Competence Network Obesity (CNO), Germany; Seca, Hamburg; Zensa Analytic, Frankfurt; EchoMRI TM, Houston; and Cosmed Companies, Fridolfing.

Funded by
German Ministry of Education and Research. Grant Number: BMBF 0315681
BMBF Competence Network Obesity (CNO)
Reference Centre of Body Composition
Körperzusammensetzung. Grant Number: FKZ 01GI1125
Canadian Institutes of Health Research
Alberta Cancer Foundation
German Research Foundation. Grant Numbers: DFG Bo 3296/1-1, DFG Mü 714/ 8-3
Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen (Ministry of Science and Research of the State of North Rhine-Westphalia)
Bundesministerium für Gesundheit (Federal Ministry of Health)
KDH
Intramural Research Program of the National Institutes of Health
National Institute of Diabetes & Digestive & Kidney Diseases
Seca, Hamburg
Zensa Analytic, Frankfurt
EchoMRI TM, Houston
Cosmed Companies, Fridolfing

Keywords

Adipose tissue
body composition
metabolism
muscle mass

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/obr.12187Licence: Unspecified

Cite this

Mueller, M. J., Baracos, V., Bosy-Westphal, A., Dulloo, A. G., Eckel, J., Fearon, K. C. H., Hall, K. D., Pietrobelli, A., Sorensen, T. I. A., Speakman, J., Trayhurn, P., Visser, M., & Heymsfield, S. B. (2014). Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany. Obesity Reviews, 15(8), 640-656. https://doi.org/10.1111/obr.12187

Mueller, MJ, Baracos, V, Bosy-Westphal, A, Dulloo, AG, Eckel, J, Fearon, KCH, Hall, KD, Pietrobelli, A, Sorensen, TIA, Speakman, J, Trayhurn, P, Visser, M & Heymsfield, SB 2014, 'Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany', Obesity Reviews, vol. 15, no. 8, pp. 640-656. https://doi.org/10.1111/obr.12187

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title = "Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany",

abstract = "The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss, there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus an understanding of body weight regulation involves an examination of the relationships between organs and tissues rather than individual organ and tissue masses only. The between organ/tissue mass relationships are associated with and explained by crosstalks between organs and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism.",

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author = "Mueller, {M. J.} and V. Baracos and A. Bosy-Westphal and Dulloo, {A. G.} and J. Eckel and Fearon, {K. C. H.} and Hall, {K. D.} and A. Pietrobelli and Sorensen, {T. I. A.} and J. Speakman and P. Trayhurn and M. Visser and Heymsfield, {S. B.}",

note = "The authors wish to thank IASO for giving them the opportunity to organize the 2013 Stock Conference. Special thanks to David York and Natasha Joyner from IASO for their help in preparing and conducting the conference. The financial support provided by the following is acknowledged: BMBF Competence Network Obesity (CNO), Germany; Seca, Hamburg; Zensa Analytic, Frankfurt; EchoMRI TM, Houston; and Cosmed Companies, Fridolfing. Funded by German Ministry of Education and Research. Grant Number: BMBF 0315681 BMBF Competence Network Obesity (CNO) Reference Centre of Body Composition K{\"o}rperzusammensetzung. Grant Number: FKZ 01GI1125 Canadian Institutes of Health Research Alberta Cancer Foundation German Research Foundation. Grant Numbers: DFG Bo 3296/1-1, DFG M{\"u} 714/ 8-3 Ministerium f{\"u}r Wissenschaft und Forschung des Landes Nordrhein-Westfalen (Ministry of Science and Research of the State of North Rhine-Westphalia) Bundesministerium f{\"u}r Gesundheit (Federal Ministry of Health) KDH Intramural Research Program of the National Institutes of Health National Institute of Diabetes & Digestive & Kidney Diseases Seca, Hamburg Zensa Analytic, Frankfurt EchoMRI TM, Houston Cosmed Companies, Fridolfing",

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AU - Bosy-Westphal, A.

AU - Dulloo, A. G.

AU - Eckel, J.

AU - Fearon, K. C. H.

AU - Hall, K. D.

AU - Pietrobelli, A.

AU - Sorensen, T. I. A.

AU - Speakman, J.

AU - Trayhurn, P.

AU - Visser, M.

AU - Heymsfield, S. B.

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AB - The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss, there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus an understanding of body weight regulation involves an examination of the relationships between organs and tissues rather than individual organ and tissue masses only. The between organ/tissue mass relationships are associated with and explained by crosstalks between organs and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism.

KW - Adipose tissue

KW - body composition

KW - metabolism

KW - muscle mass

U2 - 10.1111/obr.12187

DO - 10.1111/obr.12187

M3 - Article

SN - 1467-7881

VL - 15

SP - 640

EP - 656

JO - Obesity Reviews

JF - Obesity Reviews

IS - 8

ER -

Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this