Fundus autofluorescence in exudative age-related macular degeneration

Research output: Contribution to journalArticle

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Abstract

Aim: To evaluate the distribution of fundus autofluorescence in patients with age-related macular degeneration and choroidal neovascularisation (CNV).

Methods: Colour fundus photographs, fundus fluorescein angiograms (FFA) and fundus autofluorescence images were obtained from a group of 40 patients (43 eyes) with age-related macular degeneration and purely classic or occult CNV. Only patients with newly diagnosed CNV and in whom autofluorescence images were obtained within 2 weeks from FFA were included. The distribution of autofluorescence was qualitatively evaluated, and the findings compared with those from colour fundus photographs and FFA.

Results: 29 (67%) eyes had classic CNV and 14 (33%) had occult CNV. In 26 (90%) eyes with classic CNV, a low autofluorescence signal was detected at the site of the CNV; in 7 (50%) eyes with occult CNV, multiple foci of low autofluorescence signal were detected. Outside the area affected by the lesion, homogeneous autofluorescence was observed in most of the cases (n=33, 77%). Similarly, homogeneous autofluorescence was commonly observed in fellow eyes (62%). A pattern of focal increased autofluorescence was rarely seen in eyes with CNV (n=4, 9%) or in fellow eyes (n=4, 15%). In 11 of 43 (25%) eyes, areas of increased autofluorescence, other than a pattern of focal increased autofluorescence, were detected. In four patients, autofluorescence images had been obtained before the development of CNV; in none was any increased autofluorescence detected before the formation of CNV.

Conclusions: Distinct patterns of autofluorescence were observed in eyes with pure classic and occult CNV. Increased autofluorescence was rarely seen in eyes with CNV and in fellow eyes, suggesting that increased autofluorescence, and thus, retinal pigment epithelium lipofuscin may not play an essential part in the formation of CNV.

Original languageEnglish
Pages (from-to)491-496
Number of pages6
JournalBritish Journal of Ophthalmology
Volume91
Issue number4
Early online date6 Sep 2006
DOIs
Publication statusPublished - Apr 2007

Keywords

  • retinal-pigment epithelium
  • occult choroidal neovascularization
  • factor-H polymorphism
  • in-vivo
  • natural course
  • lipofuscin
  • disease
  • cells
  • ophthalmoscope
  • flavimaculatus

Cite this

Fundus autofluorescence in exudative age-related macular degeneration. / McBain, Vikki A.; Townend, John; Lois, Noemi.

In: British Journal of Ophthalmology, Vol. 91, No. 4, 04.2007, p. 491-496.

Research output: Contribution to journalArticle

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title = "Fundus autofluorescence in exudative age-related macular degeneration",
abstract = "Aim: To evaluate the distribution of fundus autofluorescence in patients with age-related macular degeneration and choroidal neovascularisation (CNV). Methods: Colour fundus photographs, fundus fluorescein angiograms (FFA) and fundus autofluorescence images were obtained from a group of 40 patients (43 eyes) with age-related macular degeneration and purely classic or occult CNV. Only patients with newly diagnosed CNV and in whom autofluorescence images were obtained within 2 weeks from FFA were included. The distribution of autofluorescence was qualitatively evaluated, and the findings compared with those from colour fundus photographs and FFA. Results: 29 (67{\%}) eyes had classic CNV and 14 (33{\%}) had occult CNV. In 26 (90{\%}) eyes with classic CNV, a low autofluorescence signal was detected at the site of the CNV; in 7 (50{\%}) eyes with occult CNV, multiple foci of low autofluorescence signal were detected. Outside the area affected by the lesion, homogeneous autofluorescence was observed in most of the cases (n=33, 77{\%}). Similarly, homogeneous autofluorescence was commonly observed in fellow eyes (62{\%}). A pattern of focal increased autofluorescence was rarely seen in eyes with CNV (n=4, 9{\%}) or in fellow eyes (n=4, 15{\%}). In 11 of 43 (25{\%}) eyes, areas of increased autofluorescence, other than a pattern of focal increased autofluorescence, were detected. In four patients, autofluorescence images had been obtained before the development of CNV; in none was any increased autofluorescence detected before the formation of CNV. Conclusions: Distinct patterns of autofluorescence were observed in eyes with pure classic and occult CNV. Increased autofluorescence was rarely seen in eyes with CNV and in fellow eyes, suggesting that increased autofluorescence, and thus, retinal pigment epithelium lipofuscin may not play an essential part in the formation of CNV.",
keywords = "retinal-pigment epithelium, occult choroidal neovascularization, factor-H polymorphism, in-vivo, natural course, lipofuscin, disease, cells, ophthalmoscope, flavimaculatus",
author = "McBain, {Vikki A.} and John Townend and Noemi Lois",
year = "2007",
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language = "English",
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T1 - Fundus autofluorescence in exudative age-related macular degeneration

AU - McBain, Vikki A.

AU - Townend, John

AU - Lois, Noemi

PY - 2007/4

Y1 - 2007/4

N2 - Aim: To evaluate the distribution of fundus autofluorescence in patients with age-related macular degeneration and choroidal neovascularisation (CNV). Methods: Colour fundus photographs, fundus fluorescein angiograms (FFA) and fundus autofluorescence images were obtained from a group of 40 patients (43 eyes) with age-related macular degeneration and purely classic or occult CNV. Only patients with newly diagnosed CNV and in whom autofluorescence images were obtained within 2 weeks from FFA were included. The distribution of autofluorescence was qualitatively evaluated, and the findings compared with those from colour fundus photographs and FFA. Results: 29 (67%) eyes had classic CNV and 14 (33%) had occult CNV. In 26 (90%) eyes with classic CNV, a low autofluorescence signal was detected at the site of the CNV; in 7 (50%) eyes with occult CNV, multiple foci of low autofluorescence signal were detected. Outside the area affected by the lesion, homogeneous autofluorescence was observed in most of the cases (n=33, 77%). Similarly, homogeneous autofluorescence was commonly observed in fellow eyes (62%). A pattern of focal increased autofluorescence was rarely seen in eyes with CNV (n=4, 9%) or in fellow eyes (n=4, 15%). In 11 of 43 (25%) eyes, areas of increased autofluorescence, other than a pattern of focal increased autofluorescence, were detected. In four patients, autofluorescence images had been obtained before the development of CNV; in none was any increased autofluorescence detected before the formation of CNV. Conclusions: Distinct patterns of autofluorescence were observed in eyes with pure classic and occult CNV. Increased autofluorescence was rarely seen in eyes with CNV and in fellow eyes, suggesting that increased autofluorescence, and thus, retinal pigment epithelium lipofuscin may not play an essential part in the formation of CNV.

AB - Aim: To evaluate the distribution of fundus autofluorescence in patients with age-related macular degeneration and choroidal neovascularisation (CNV). Methods: Colour fundus photographs, fundus fluorescein angiograms (FFA) and fundus autofluorescence images were obtained from a group of 40 patients (43 eyes) with age-related macular degeneration and purely classic or occult CNV. Only patients with newly diagnosed CNV and in whom autofluorescence images were obtained within 2 weeks from FFA were included. The distribution of autofluorescence was qualitatively evaluated, and the findings compared with those from colour fundus photographs and FFA. Results: 29 (67%) eyes had classic CNV and 14 (33%) had occult CNV. In 26 (90%) eyes with classic CNV, a low autofluorescence signal was detected at the site of the CNV; in 7 (50%) eyes with occult CNV, multiple foci of low autofluorescence signal were detected. Outside the area affected by the lesion, homogeneous autofluorescence was observed in most of the cases (n=33, 77%). Similarly, homogeneous autofluorescence was commonly observed in fellow eyes (62%). A pattern of focal increased autofluorescence was rarely seen in eyes with CNV (n=4, 9%) or in fellow eyes (n=4, 15%). In 11 of 43 (25%) eyes, areas of increased autofluorescence, other than a pattern of focal increased autofluorescence, were detected. In four patients, autofluorescence images had been obtained before the development of CNV; in none was any increased autofluorescence detected before the formation of CNV. Conclusions: Distinct patterns of autofluorescence were observed in eyes with pure classic and occult CNV. Increased autofluorescence was rarely seen in eyes with CNV and in fellow eyes, suggesting that increased autofluorescence, and thus, retinal pigment epithelium lipofuscin may not play an essential part in the formation of CNV.

KW - retinal-pigment epithelium

KW - occult choroidal neovascularization

KW - factor-H polymorphism

KW - in-vivo

KW - natural course

KW - lipofuscin

KW - disease

KW - cells

KW - ophthalmoscope

KW - flavimaculatus

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DO - 10.1136/bjo.2006.095109

M3 - Article

VL - 91

SP - 491

EP - 496

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 4

ER -