Fungal cell wall an underexploited target for antifungal therapies

Chibuike Ibe, Carol Munro

Research output: Contribution to journalArticlepeer-review

Abstract

The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of the cell wall and appear perpendicular to the cell surface forming a fibrillar protein coat (Fig.1A). The polysaccharide rich inner layer is mainly made up of β-1,6- and β-1,3-glucans and chitin while β-1,3-glucans and chitin are the structural polysaccharides in the cell wall.
Original languageEnglish
JournalPLoS Pathogens
Publication statusAccepted/In press - 12 Mar 2021

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