Fungal cell wall: An underexploited target for antifungal therapies

Chibuike Ibe; Carol Munro

doi:10.1371/journal.ppat.1009470

Fungal cell wall: An underexploited target for antifungal therapies

Chibuike Ibe^* (Corresponding Author), Carol Munro

^*Corresponding author for this work

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Abstract

The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of the cell wall and appear perpendicular to the cell surface forming a fibrillar protein coat (Fig.1A). The polysaccharide rich inner layer is mainly made up of β-1,6- and β-1,3-glucans and chitin while β-1,3-glucans and chitin are the structural polysaccharides in the cell wall.

Original language	English
Article number	e1009470
Number of pages	7
Journal	PLoS Pathogens
Volume	17
Issue number	4
DOIs	https://doi.org/10.1371/journal.ppat.1009470
Publication status	Published - 22 Apr 2021

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10.1371/journal.ppat.1009470Licence: CC BY

Ibe_etal_PLOSP_Fungal_cell_wall_VOR
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/4.0/
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abstract = "The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of the cell wall and appear perpendicular to the cell surface forming a fibrillar protein coat (Fig.1A). The polysaccharide rich inner layer is mainly made up of β-1,6- and β-1,3-glucans and chitin while β-1,3-glucans and chitin are the structural polysaccharides in the cell wall.",

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note = "Funding: The authors would like to acknowledge support from the University of Aberdeen and Abia State University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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AB - The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of the cell wall and appear perpendicular to the cell surface forming a fibrillar protein coat (Fig.1A). The polysaccharide rich inner layer is mainly made up of β-1,6- and β-1,3-glucans and chitin while β-1,3-glucans and chitin are the structural polysaccharides in the cell wall.

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Fungal cell wall: An underexploited target for antifungal therapies

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