Fungal echinocandin resistance

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Abstract

Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of ß-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the production of chitin, the second structural cell wall polysaccharide.
Original languageEnglish
Article number66
Number of pages3
JournalF1000 Biology Reports
Volume2
DOIs
Publication statusPublished - 8 Sep 2010

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