Abstract
Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of ß-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the production of chitin, the second structural cell wall polysaccharide.
Original language | English |
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Article number | 66 |
Number of pages | 3 |
Journal | F1000 Biology Reports |
Volume | 2 |
DOIs | |
Publication status | Published - 8 Sept 2010 |