Fungal model systems and the elucidation of pathogenicity determinants

Elena Perez-Nadales, Maria Filomena Almeida Nogueira, Clara Baldin, Sónia Castanheira, Mennat El Ghalid, Elisabeth Grund, Klaus Lengeler, Elisabetta Marchegiani, Pankaj Vinod Mehrotra, Marino Moretti, Vikram Naik, Miriam Oses-Ruiz, Therese Oskarsson, Katja Schafer, Lisa Wasserstrom, Axel A Brakhage, Neil A R Gow, Regine Kahmann, Marc-Henri Lebrun, José Perez-MartinAntonio Di Pietro, Nicholas J Talbot, Valerie Toquin, Andrea Walther, Jürgen Wendland

Research output: Contribution to journalArticle

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Abstract

Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity.

Original languageEnglish
Pages (from-to)42-67
Number of pages26
JournalFungal Genetics and Biology
Volume70
Early online date7 Jul 2014
DOIs
Publication statusPublished - Sep 2014

Fingerprint

Virulence
Magnaporthe
Ustilago
Plant Diseases
Animal Diseases
Aspergillus fumigatus
Food Supply
Mycoses
Fusarium
Candida albicans
Fungi
Mortality
Research
Pharmaceutical Preparations
Oryza

Keywords

  • Chromosomes, Fungal
  • Fungi
  • Genome, Fungal
  • Mitogen-Activated Protein Kinase Kinases
  • Secondary Metabolism
  • Virulence

Cite this

Perez-Nadales, E., Nogueira, M. F. A., Baldin, C., Castanheira, S., El Ghalid, M., Grund, E., ... Wendland, J. (2014). Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genetics and Biology, 70, 42-67. https://doi.org/10.1016/j.fgb.2014.06.011

Fungal model systems and the elucidation of pathogenicity determinants. / Perez-Nadales, Elena; Nogueira, Maria Filomena Almeida; Baldin, Clara; Castanheira, Sónia; El Ghalid, Mennat; Grund, Elisabeth; Lengeler, Klaus; Marchegiani, Elisabetta; Mehrotra, Pankaj Vinod; Moretti, Marino; Naik, Vikram; Oses-Ruiz, Miriam; Oskarsson, Therese; Schafer, Katja; Wasserstrom, Lisa; Brakhage, Axel A; Gow, Neil A R; Kahmann, Regine; Lebrun, Marc-Henri; Perez-Martin, José; Di Pietro, Antonio; Talbot, Nicholas J; Toquin, Valerie; Walther, Andrea; Wendland, Jürgen.

In: Fungal Genetics and Biology, Vol. 70, 09.2014, p. 42-67.

Research output: Contribution to journalArticle

Perez-Nadales, E, Nogueira, MFA, Baldin, C, Castanheira, S, El Ghalid, M, Grund, E, Lengeler, K, Marchegiani, E, Mehrotra, PV, Moretti, M, Naik, V, Oses-Ruiz, M, Oskarsson, T, Schafer, K, Wasserstrom, L, Brakhage, AA, Gow, NAR, Kahmann, R, Lebrun, M-H, Perez-Martin, J, Di Pietro, A, Talbot, NJ, Toquin, V, Walther, A & Wendland, J 2014, 'Fungal model systems and the elucidation of pathogenicity determinants', Fungal Genetics and Biology, vol. 70, pp. 42-67. https://doi.org/10.1016/j.fgb.2014.06.011
Perez-Nadales E, Nogueira MFA, Baldin C, Castanheira S, El Ghalid M, Grund E et al. Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genetics and Biology. 2014 Sep;70:42-67. https://doi.org/10.1016/j.fgb.2014.06.011
Perez-Nadales, Elena ; Nogueira, Maria Filomena Almeida ; Baldin, Clara ; Castanheira, Sónia ; El Ghalid, Mennat ; Grund, Elisabeth ; Lengeler, Klaus ; Marchegiani, Elisabetta ; Mehrotra, Pankaj Vinod ; Moretti, Marino ; Naik, Vikram ; Oses-Ruiz, Miriam ; Oskarsson, Therese ; Schafer, Katja ; Wasserstrom, Lisa ; Brakhage, Axel A ; Gow, Neil A R ; Kahmann, Regine ; Lebrun, Marc-Henri ; Perez-Martin, José ; Di Pietro, Antonio ; Talbot, Nicholas J ; Toquin, Valerie ; Walther, Andrea ; Wendland, Jürgen. / Fungal model systems and the elucidation of pathogenicity determinants. In: Fungal Genetics and Biology. 2014 ; Vol. 70. pp. 42-67.
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AU - Di Pietro, Antonio

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