Future dentistry: cell therapy meets tooth and periodontal repair and regeneration

Javier Catón, Nagihan Bostanci, Eumorphia Remboutsika, Cosimo De Bari, Thimios A Mitsiadis

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Cell-based tissue repair of the tooth and -tooth-supporting- periodontal ligament is a new attractive approach that complements traditional restorative or surgical techniques for replacement of injured or pathologically damaged tissues. In such therapeutic approaches, stem cells and/or progenitor cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review we discuss the clonogenic potential of human dental and periodontal tissues such as the dental pulp and the periodontal ligament and their potential for tooth and periodontal repair and/or regeneration. We propose novel therapeutic approaches using stem cells or progenitor cells, which are targeted to regenerate the lost dental or periodontal tissue.
Original languageEnglish
Pages (from-to)1054-1065
Number of pages12
JournalJournal of Cellular and Molecular Medicine
Volume15
Issue number5
DOIs
Publication statusPublished - May 2011

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Keywords

  • tooth
  • odontoblast
  • periodontal ligament
  • stem cells
  • dental pulp
  • implants

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