Gastrointestinal tract

intestinal fatty acid metabolism and implications for health

L. Hoyles, R. J. Wallace

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Short-chain fatty acids (SCFA) are formed from the fermentation of sugars by intestinal bacteria. Acetate is the most abundant SCFA, with lower amounts of propionate and butyrate formed. Propionate and butyrate are also formed from the products of carbohydrate fermentation by other bacteria, for example from lactate and acetate. SCFA play a role in regulating transit of digesta through the intestine, and butyrate formation is thought to be beneficial to health because butyrate decreases the risk of colon cancer. Major butyrate-producing species are among the most abundant present in the colon, including Roseburia and Faecalibacterium spp. Metabolism of longer-chain fatty acids occurs mainly by hydration or hydrogenation of unsaturated fatty acids. Hydroxystearic acids are formed in the intestine, particularly under disease conditions. Metabolism of linoleic acid results in the formation of conjugated linoleic acids (CLA) by several species, including Roseburia hominis and Roseburia inulinovorans. Enhancement of intestinal CLA formation, possibly using probiotics, may be useful in preventing or treating inflammatory bowel disease.
Original languageEnglish
Title of host publicationHandbook of Hydrocarbon and Lipid Microbiology
EditorsK. N. Timmis
Place of PublicationBerlin, Germany
PublisherSpringer-Verlag
Pages 3119-3132
Number of pages14
ISBN (Electronic)978-3540775874
ISBN (Print)3540775846, 978-3540775843
DOIs
Publication statusPublished - 3 Dec 2009

Publication series

NameHandbook of Hydrocarbon and Lipid Microbiology
PublisherSpringer-Verlag
Number29

Fingerprint

fatty acid
metabolism
acid
fermentation
acetate
bacterium
probiotics
hydration
carbohydrate
cancer
sugar
health

Cite this

Hoyles, L., & Wallace, R. J. (2009). Gastrointestinal tract: intestinal fatty acid metabolism and implications for health. In K. N. Timmis (Ed.), Handbook of Hydrocarbon and Lipid Microbiology (pp. 3119-3132). (Handbook of Hydrocarbon and Lipid Microbiology; No. 29). Berlin, Germany: Springer-Verlag. https://doi.org/10.1007/978-3-540-77587-4_234

Gastrointestinal tract : intestinal fatty acid metabolism and implications for health. / Hoyles, L.; Wallace, R. J.

Handbook of Hydrocarbon and Lipid Microbiology. ed. / K. N. Timmis. Berlin, Germany : Springer-Verlag, 2009. p. 3119-3132 (Handbook of Hydrocarbon and Lipid Microbiology; No. 29).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hoyles, L & Wallace, RJ 2009, Gastrointestinal tract: intestinal fatty acid metabolism and implications for health. in KN Timmis (ed.), Handbook of Hydrocarbon and Lipid Microbiology. Handbook of Hydrocarbon and Lipid Microbiology, no. 29, Springer-Verlag, Berlin, Germany, pp. 3119-3132. https://doi.org/10.1007/978-3-540-77587-4_234
Hoyles L, Wallace RJ. Gastrointestinal tract: intestinal fatty acid metabolism and implications for health. In Timmis KN, editor, Handbook of Hydrocarbon and Lipid Microbiology. Berlin, Germany: Springer-Verlag. 2009. p. 3119-3132. (Handbook of Hydrocarbon and Lipid Microbiology; 29). https://doi.org/10.1007/978-3-540-77587-4_234
Hoyles, L. ; Wallace, R. J. / Gastrointestinal tract : intestinal fatty acid metabolism and implications for health. Handbook of Hydrocarbon and Lipid Microbiology. editor / K. N. Timmis. Berlin, Germany : Springer-Verlag, 2009. pp. 3119-3132 (Handbook of Hydrocarbon and Lipid Microbiology; 29).
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